Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapour diffusion method using 25% PEG-3350, 0.2 M LiSO4, and 100 mM Bis-Tris, pH 5.5, or 0.15 M malic acid, pH 7.0, 20% PEG-3350 and 2.0 M (NH4)H2PO4, 0.1 M Tris/HCl, pH 8.5 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic acid | 36% residual activity at 0.1 mM; 3% residual activity at 0.1 mM; 7% residual activity at 0.1 mM; 9% residual activity at 0.1 mM | Homo sapiens | |
2-chloro-4-(2,5-dimethyl-1H-pyrrol-1-yl) benzoic acid | 36% residual activity at 0.1 mM; 46% residual activity at 0.1 mM; 95% residual activity at 0.1 mM; 98% residual activity at 0.1 mM | Homo sapiens | |
2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl) benzoic acid | 37% residual activity at 0.1 mM; 77% residual activity at 0.1 mM; 88% residual activity at 0.1 mM; 91% residual activity at 0.1 mM | Homo sapiens | |
3-(2,5-dimethyl-1H-pyrrol-1-yl)-4-hydroxybenzoic acid | 20% residual activity at 0.1 mM; 3% residual activity at 0.1 mM; 52% residual activity at 0.1 mM; 7% residual activity at 0.1 mM | Homo sapiens | |
3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,6-dicarboxylic acid | 25% residual activity at 0.1 mM; 39% residual activity at 0.1 mM; 65% residual activity at 0.1 mM; 73% residual activity at 0.1 mM | Homo sapiens | |
3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,8-dicarboxylic acid | 30% residual activity at 0.1 mM; 53% residual activity at 0.1 mM; 63% residual activity at 0.1 mM; 79% residual activity at 0.1 mM | Homo sapiens | |
3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 23% residual activity at 0.1 mM; 75% residual activity at 0.1 mM; 80% residual activity at 0.1 mM; 9% residual activity at 0.1 mM | Homo sapiens | |
4-(2,5-dimethyl-1H-pyrrol-1-yl) benzoic acid | 63% residual activity at 0.1 mM; 6% residual activity at 0.1 mM; 88% residual activity at 0.1 mM; 9% residual activity at 0.1 mM | Homo sapiens | |
4-(2,5-dimethyl-1H-pyrrol-1-yl)-3-hydroxybenzoic acid | 21% residual activity at 0.1 mM; 67% residual activity at 0.1 mM; 72% residual activity at 0.1 mM; 9% residual activity at 0.1 mM | Homo sapiens | |
4-(2,5-dimethyl-1H-pyrrol-1-yl)phthalic acid | 18% residual activity at 0.1 mM; 54% residual activity at 0.1 mM; 78% residual activity at 0.1 mM; 80% residual activity at 0.1 mM | Homo sapiens | |
5-acetylamino-2-(2,5-dimethyl-1H-pyrrol-1-yl) benzoic acid | 45% residual activity at 0.1 mM; 46% residual activity at 0.1 mM; 82% residual activity at 0.1 mM; 94% residual activity at 0.1 mM | Homo sapiens | |
6-fluoro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 35% residual activity at 0.1 mM; 63% residual activity at 0.1 mM; 72% residual activity at 0.1 mM; 75% residual activity at 0.1 mM | Homo sapiens | |
6-hydroxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylate | 80% residual activity at 0.1 mM | Homo sapiens | |
6-hydroxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 38% residual activity at 0.1 mM; 50% residual activity at 0.1 mM; 73% residual activity at 0.1 mM | Homo sapiens | |
8-acetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 48% residual activity at 0.1 mM; 66% residual activity at 0.1 mM; 81% residual activity at 0.1 mM; 83% residual activity at 0.1 mM | Homo sapiens | |
8-bromo-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid | 33% residual activity at 0.1 mM; 41% residual activity at 0.1 mM; 8% residual activity at 0.1 mM; 90% residual activity at 0.1 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni2+-Sepharose affinity HiTrap HP column chromatography, Superdex 200 16/60 gel filtration, DEAE-cellulose resin chromatography, and HiTrapQ column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,8-difluoro-4-methylumbelliferyl phosphate + H2O | - |
Homo sapiens | 6,8-difluoro-4-methylumbelliferone + phosphate | - |
? | |
p-nitrophenyl phosphate | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | x-ray crystallography | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
PTPN5 | - |
Homo sapiens |
PTPN7 | - |
Homo sapiens |
PTPRR | - |
Homo sapiens |
STEP | - |
Homo sapiens |
striatal-enriched PTP | - |
Homo sapiens |