Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-methyl-2-butenal | 95% remaining activity at 0.5 mM | Homo sapiens | |
acetaldehyde | more than 95% remaining activity at 0.5 mM | Homo sapiens | |
acrolein | 4% remaining activity at 0.5 mM, potent irreversible time-dependent inhibitor, addition of 1 mM vanadate slows inactivation of PTP1B by 0.5 mM acrolein | Homo sapiens | |
crotonaldehyde | 85% remaining activity at 0.5 mM | Homo sapiens | |
Glyoxal | 93% remaining activity at 0.5 mM | Homo sapiens | |
additional information | the presence of the superoxide- and hydrogen peroxide-destroying enzymes superoxide dismutase and catalase has no effect on the rate of the inactivation reaction | Homo sapiens | |
propanal | 93% remaining activity at 0.5 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
p-nitrophenyl phosphate + H2O | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00023 | - |
acrolein | in sodium acetate (100 mM), bis-Tris (50 mM), Tris (50 mM), diethylenetriaminepentaacetic acid (5 mM), and 2,5-dimethylfuran (5% v/v), at pH 7 and 25°C | Homo sapiens |