Activating Compound | Comment | Organism | Structure |
---|---|---|---|
UpA | uPA regulates SHP-2 phosphorylation, stimulates its catalytic activity and association with PDGFR-beta and with lipid rafts | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
nucleus | SHP-2 can dephosphorylate STAT1 in cell nucleus | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | - |
Homo sapiens | - |
VSMC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
phosphorylated platelet-derived growth factor receptor + H2O | - |
Homo sapiens | platelet-derived growth factor receptor + phosphate | - |
? | |
phosphorylated STAT1 + H2O | - |
Homo sapiens | STAT1 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PTK | - |
Homo sapiens |
Scr homology 2-containing tyrosine phosphatase | - |
Homo sapiens |
SHP-2 | - |
Homo sapiens |
tyrosine phosphatase | - |
Homo sapiens |