Literature summary for 3.1.3.48 extracted from

Kunnumakkara, A.B.; Nair, A.S.; Sung, B.; Pandey, M.K.; Aggarwal, B.B.
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1 (2009), Mol. Cancer Res., 7, 118-128.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	acetyl 11-keto-beta-boswellic acid induces SHP-1 both at transcriptional and translational level in a dose-dependent manner	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
sodium pervanadate	broad-acting tyrosine phosphatase inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
multiple myeloma cell	-	Homo sapiens	-
U-266 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphorylated STAT3 + H2O	-	Homo sapiens	STAT3 + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
protein tyrosine phosphatase	-	Homo sapiens
PTP	-	Homo sapiens
SHP-1	SHP-1 is a nontransmembrane PTP	Homo sapiens
Src homology region 2 domain-containing phosphatase 1	-	Homo sapiens

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Release 2023.1 (January 2023)