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Literature summary for 3.1.3.48 extracted from

  • Mattila, E.; Marttila, H.; Sahlberg, N.; Kohonen, P.; Taehtinen, S.; Halonen, P.; Peraelae, M.; Ivaska, J.
    Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase (2010), BMC Cancer, 10, 7.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Mitoxantrone activates isozyme TC45 via a mechanism similar to alpha1-cyt, i.e. integrin alpha1 cytoplasmic tail residues 1164-1179, molecular mechanism, overview Mus musculus
additional information interaction between the alpha-cytoplasmic tail of a1beta1 integrin and TCPTP activates TCPTP by disrupting an inhibitory intramolecular bond in TCPTP Mus musculus
spermidine activates isozyme TC45 via a mechanism similar to alpha1-cyt, i.e. integrin alpha1 cytoplasmic tail residues 1164-1179, molecular mechanism, overview. Spermidine inhibits serum-induced cell proliferation in a TC45-dependent manner, and regulates EGFR and PDGFRb signalling via TC45 Mus musculus

Application

Application Comment Organism
pharmacology inhibition of the regulatory interaction in TCPTP is a desirable strategy for TCPTP activation and attenuation of oncogenic receptor tyrosine kinase signalling Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information interaction between the alpha-cytoplasmic tail of a1beta1 integrin and TCPTP activates TCPTP by disrupting an inhibitory intramolecular bond in TCPTP, screening of screened 64280 small molecules for TCPTP inhibition, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus 45 kDa isozyme Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
isozyme TC45
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
Mus musculus
-
fibroblast
-
Mus musculus
-
MEF cell
-
Mus musculus
-
T-lymphocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
-
Mus musculus 6,8-difluoro-4-methylumbelliferol + phosphate
-
?

Synonyms

Synonyms Comment Organism
non-receptor protein tyrosine phosphatase
-
Mus musculus
protein tyrosine phosphatase
-
Mus musculus
T-cell protein tyrosine phosphatase
-
Mus musculus
TCPTP
-
Mus musculus
TCPTP/TC45
-
Mus musculus

General Information

General Information Comment Organism
malfunction the enzyme is involved in the negative regulation of several cancer relevant cellular signalling pathways Mus musculus