Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Mitoxantrone | activates isozyme TC45 via a mechanism similar to alpha1-cyt, i.e. integrin alpha1 cytoplasmic tail residues 1164-1179, molecular mechanism, overview | Mus musculus | |
additional information | interaction between the alpha-cytoplasmic tail of a1beta1 integrin and TCPTP activates TCPTP by disrupting an inhibitory intramolecular bond in TCPTP | Mus musculus | |
spermidine | activates isozyme TC45 via a mechanism similar to alpha1-cyt, i.e. integrin alpha1 cytoplasmic tail residues 1164-1179, molecular mechanism, overview. Spermidine inhibits serum-induced cell proliferation in a TC45-dependent manner, and regulates EGFR and PDGFRb signalling via TC45 | Mus musculus |
Application | Comment | Organism |
---|---|---|
pharmacology | inhibition of the regulatory interaction in TCPTP is a desirable strategy for TCPTP activation and attenuation of oncogenic receptor tyrosine kinase signalling | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | interaction between the alpha-cytoplasmic tail of a1beta1 integrin and TCPTP activates TCPTP by disrupting an inhibitory intramolecular bond in TCPTP, screening of screened 64280 small molecules for TCPTP inhibition, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | 45 kDa isozyme | Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozyme TC45 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Mus musculus | - |
fibroblast | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
T-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,8-difluoro-4-methylumbelliferyl phosphate + H2O | - |
Mus musculus | 6,8-difluoro-4-methylumbelliferol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
non-receptor protein tyrosine phosphatase | - |
Mus musculus |
protein tyrosine phosphatase | - |
Mus musculus |
T-cell protein tyrosine phosphatase | - |
Mus musculus |
TCPTP | - |
Mus musculus |
TCPTP/TC45 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | the enzyme is involved in the negative regulation of several cancer relevant cellular signalling pathways | Mus musculus |