Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of PTPH1 knockout mice, no immunological phenotype in primary T cells derived from PTPH1-KO mice, carrageenan induces a trend of slightly increased spontaneous pain sensitivity in PTPH1-KO mice compared to wild-type littermates, but no differences in cytokine release, induced pain perception and cellular infiltration, but LPS-induced TNFalpha, MCP-1, and IL10 release is significantly reduced in PTPH1-KO plasma compared to wild-type plasma, overview | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | PTPH1 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated TCRzeta + H2O | PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway | Mus musculus | TCRzeta + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase H1 | - |
Mus musculus |
PTPH1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | PTPH1 might play a role in the positive regulation of the LPS-induced cytokines release in vivo, in contrast to previous reports indicating PTPH1 as potential negative regulator of immune response | Mus musculus |