Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3beta)-3-(acetyloxy)olean-12-en-28-oic acid | - |
Homo sapiens | |
(3beta)-3-hydroxyolean-12-en-28-oic acid | - |
Homo sapiens | |
(3beta)-3-hydroxyoleana-11,13(18)-dien-28-oic acid | - |
Homo sapiens | |
(4aR,6aR,6bS,8aR,12aS,14aR,14bR)-8a-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,4a,5,6,6a,6b,7,8a,9,10,11,12,12a,14,14a,14b-hexadecahydropicene-3,8(2H,4H)-dione | - |
Homo sapiens | |
(4aR,6aS,6bR,8aR,10S,12aR,12bR,14bS)-4a,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicen-5(1H)-one | - |
Homo sapiens | |
(6aS,6bR,8aR,10S,12aS,12bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b-hexadecahydropicen-5(1H)-one | - |
Homo sapiens | |
3,16-dioxo-olean-12(13),17(18)-diene | - |
Homo sapiens | |
3beta,16a,17-trihydroxy-olean-12-ene | - |
Homo sapiens | |
additional information | not inhibited by camelliaolean A and camelliaolean B | Homo sapiens | |
ursolic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[a protein]-tyrosine phosphate + H2O | Homo sapiens | - |
[a protein]-tyrosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
[a protein]-tyrosine phosphate + H2O | - |
Homo sapiens | [a protein]-tyrosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00374 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | ursolic acid | |
0.00377 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | (4aR,6aS,6bR,8aR,10S,12aR,12bR,14bS)-4a,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicen-5(1H)-one | |
0.00394 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | 3beta,16a,17-trihydroxy-olean-12-ene | |
0.00466 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | (6aS,6bR,8aR,10S,12aS,12bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b-hexadecahydropicen-5(1H)-one | |
0.00479 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | (3beta)-3-(acetyloxy)olean-12-en-28-oic acid | |
0.00534 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | (3beta)-3-hydroxyolean-12-en-28-oic acid | |
0.0064 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | (3beta)-3-hydroxyoleana-11,13(18)-dien-28-oic acid | |
0.01623 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | 3,16-dioxo-olean-12(13),17(18)-diene | |
0.03 | - |
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C | Homo sapiens | (4aR,6aR,6bS,8aR,12aS,14aR,14bR)-8a-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,4a,5,6,6a,6b,7,8a,9,10,11,12,12a,14,14a,14b-hexadecahydropicene-3,8(2H,4H)-dione |