Literature summary for 3.1.3.48 extracted from

Wang, F.; Xue, R.; Li, X.; Hu, C.; Xia, Q.
Characterization of a protein tyrosine phosphatase as a host factor promoting baculovirus replication in silkworm, Bombyx mori (2016), Dev. Comp. Immunol., 57, 31-37 .

Cloned(Commentary)

Cloned (Comment)	Organism
gene Bmptp-h, functional recombinant overexpression of N-terminally FLAG-tagged enzyme in Bombyx mori larvae, transfection via dsRNA injection into larvae or viral infection method, quantitative real-time PCR expression analysis and expression profile of Bmptp-h during the development and in different tissues, overview. Recombinant expression of Flag-tagged BmPTP-h in BmE cells via viral transfection, overexpression of Bmptp-h enhances Bombyx mori nucleopolyhedrovirus (BmNPV) replication in BmE cells	Bombyx mori

Cloned (Comment)

Organism

gene Bmptp-h, functional recombinant overexpression of N-terminally FLAG-tagged enzyme in Bombyx mori larvae, transfection via dsRNA injection into larvae or viral infection method, quantitative real-time PCR expression analysis and expression profile of Bmptp-h during the development and in different tissues, overview. Recombinant expression of Flag-tagged BmPTP-h in BmE cells via viral transfection, overexpression of Bmptp-h enhances Bombyx mori nucleopolyhedrovirus (BmNPV) replication in BmE cells

Bombyx mori

Organism

Organism	UniProt	Comment	Textmining
Bombyx mori	Q75T82	-	-

Synonyms

Synonyms	Comment	Organism
Bmptp-h	-	Bombyx mori
protein tyrosine phosphatase	-	Bombyx mori
PTP	-	Bombyx mori

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Bombyx mori

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Bombyx mori

General Information

General Information	Comment	Organism
evolution	among the 36 PTP genes, gene ptp-h, which is proposed to be the origin of baculovirus ptp, belongs to atypical VH1-like dual-specific PTP subset and encodes a catalytic active protein. PTP variants and subfamilies in Bombyx mori, overview	Bombyx mori
physiological function	recombinant overexpression of enzyme Bmptp-h enhances BmNPV replication in BmE cells. Enzyme BmPTP-h acts as a host factor facilitating baculovirus infection via promoting its DNA replication, the enzyme is involved in the host-virus interactions that control the viral replication	Bombyx mori