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Literature summary for 3.1.3.5 extracted from

  • Russo-Abrahao, T.; Cosentino-Gomes, D.; Gomes, M.T.; Alviano, D.S.; Alviano, C.S.; Lopes, A.H.; Meyer-Fernandes, J.R.
    Biochemical properties of Candida parapsilosis ecto-5'-nucleotidase and the possible role of adenosine in macrophage interaction (2011), FEMS Microbiol. Lett., 317, 34-42.
    View publication on PubMed
Search for more literature for 3.1.3.5

Inhibitors

Inhibitors Comment Organism Structure
Ammonium molybdate
-
 Candida parapsilosis
additional information no inhibition by sodium orthovanadate Candida parapsilosis

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ enzyme activity is increased by about 42% with addition of Mg2+ or Ca2+ Candida parapsilosis
Mg2+ enzyme activity is increased by about 42% with addition of Mg2+ or Ca2+ Candida parapsilosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-AMP + H2O Candida parapsilosis
-
 adenosine + phosphate
-
 ?
5'-AMP + H2O Candida parapsilosis CCT 3834
-
 adenosine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Candida parapsilosis
-
 ATCC 22019
-
Candida parapsilosis CCT 3834
-
 ATCC 22019
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 pH 4.5, intact cells hydrolyze 5'-AMP at a rate of 52.4 nmol phosphate/h/10_7 cells. 5'-AMP, 5'-IMP and 5'-UMP are hydrolyzed at similar rates, whereas 5'-GMP and 5'-CMP are hydrolyzed at lower rates Candida parapsilosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Candida parapsilosis adenosine + phosphate
-
 ?
5'-AMP + H2O
-
 Candida parapsilosis CCT 3834 adenosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ecto-5'-nucleotidase
-
 Candida parapsilosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Candida parapsilosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
 assay at Candida parapsilosis

General Information

General Information Comment Organism
physiological function the ecto-5'-nucleotidase plays a role in the control of extracellular nucleotide concentrations in the cell and is involved in the release of free adenosine into extracellular medium Candida parapsilosis