Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | feed-forward inhibition | Rattus norvegicus | |
ATP | feed-forward inhibition | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-AMP + H2O | Rattus norvegicus | - |
adenosine + phosphate | - |
? | |
5'-AMP + H2O | Rattus norvegicus Wistar | - |
adenosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Wistar | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Rattus norvegicus | - |
brain | presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-AMP + H2O | - |
Rattus norvegicus | adenosine + phosphate | - |
? | |
5'-AMP + H2O | - |
Rattus norvegicus Wistar | adenosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD73 | - |
Rattus norvegicus |
e-5NT | - |
Rattus norvegicus |
ecto-5'-nucleotidase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | unilateral cortical stab injury causes a rapid and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression, accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for upregulation of the enzyme levels in the injured area. CSI induces dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after cortical stab injury | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the key and rate-limiting enzyme in the ectonucleotidase pathway is ecto-5'-nucleotidase, which catalyzes the final step of dephosphorylation of AMP to adenosine | Rattus norvegicus |
additional information | unilateral cortical stab injury causes a rapid and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression, accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for upregulation of the enzyme levels in the injured area. CSI induces dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after cortical stab injury | Rattus norvegicus |