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Literature summary for 3.1.3.5 extracted from

  • Bjelobaba, I.; Parabucki, A.; Lavrnja, I.; Stojkov, D.; Dacic, S.; Pekovic, S.; Rakic, L.; Stojiljkovic, M.; Nedeljkovic, N.
    Dynamic changes in the expression pattern of ecto-5'-nucleotidase in the rat model of cortical stab injury (2011), J. Neurosci. Res., 89, 862-873.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP feed-forward inhibition Rattus norvegicus
ATP feed-forward inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-AMP + H2O Rattus norvegicus
-
adenosine + phosphate
-
?
5'-AMP + H2O Rattus norvegicus Wistar
-
adenosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Wistar
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
Rattus norvegicus
-
brain presence of the enzyme in the membranes surrounding neuronal somata and apical dendrites and less frequently in astrocytes Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
Rattus norvegicus adenosine + phosphate
-
?
5'-AMP + H2O
-
Rattus norvegicus Wistar adenosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
CD73
-
Rattus norvegicus
e-5NT
-
Rattus norvegicus
ecto-5'-nucleotidase
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus unilateral cortical stab injury causes a rapid and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression, accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for upregulation of the enzyme levels in the injured area. CSI induces dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after cortical stab injury up

General Information

General Information Comment Organism
metabolism the key and rate-limiting enzyme in the ectonucleotidase pathway is ecto-5'-nucleotidase, which catalyzes the final step of dephosphorylation of AMP to adenosine Rattus norvegicus
additional information unilateral cortical stab injury causes a rapid and irreversible loss of the enzyme from neurons, accounting for a decrease in the overall enzyme expression, accompanied with a gradual increase in e-5NT-positive astrocytes, accounting for upregulation of the enzyme levels in the injured area. CSI induces dynamic changes in the expression pattern of e-5NT that modify the ATP/adenosine ratio and the extent of P1 and P2 receptors activation and, therefore, outcome of the pathological processes after cortical stab injury Rattus norvegicus