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Literature summary for 3.1.3.59 extracted from
- Formation of 1-alkyl-2-acetyl-sn-glycerols via the de novo biosynthetic pathway for platelet-activating factor. Characterization of 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase in rat spleens (1988), J. Biol. Chem., 263, 1755-1760.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | above 0.5 mM | Rattus norvegicus |  |
| Mg2+ | above 0.5 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0318 | - |
1-Alkyl-2-acetyl-sn-glycero-3-phosphate | pH 6.6-7.0, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | 53% of the total activity | Rattus norvegicus | - |
- |
| mitochondrion | 28% of the total activity | Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| kidney | medulla and cortex | Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O | no substrate selectivity with regard to variations in alkyl chain length, C16:0 versus C18:0, at the sn-1 position or short chain acyl groups, C2:0 to C6:0 with the exception of C3:0, at the sn-2 position of the glycerol moiety | Rattus norvegicus | 1-alkyl-2-acetyl-sn-glycerol + phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 80 | - |
activity destroyed | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | 7 | in homogenates and microsomal fractions of rat spleens, when ethanol is not included in the assay mixture | Rattus norvegicus |
| 7.4 | - |
microsomal fraction in 5% ethanol | Rattus norvegicus |
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