Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 35.1% of maximal activity with 0.1 mM denaturated DNA, 74.7% with 0.5 mM polydeoxythymidylic acid as substrate, competitive inhibition | Homo sapiens | |
Cu2+ | 46.0% of maximal activity with 0.1 mM denaturated DNA, 56.0% with 0.5 mM polydeoxythymidylic acid as substrate, noncompetitive inhibition | Homo sapiens | |
Fe2+ | 47.7% of maximal activity with 0.1 mM denaturated DNA, almost no activity with 0.5 mM polydeoxythymidylic acid as substrate, noncompetitive inhibition | Homo sapiens | |
Hg2+ | 31.5% of maximal activity with 0.1 mM denaturated DNA, 48.2% with 0.5 mM polydeoxythymidylic acid as substrate, competitive inhibition | Homo sapiens | |
Mn2+ | 6.5% of maximal activity with 0.1 mM denaturated DNA, 8.4% with 0.5 mM polydeoxythymidylic acid as substrate, competitive inhibition | Homo sapiens | |
N-ethylmaleimide | with 5 mM 67% reduction of hydrolysis of polydeoxythymidylic acid | Homo sapiens | |
NaCl | inhibition of polydeoxythymidylic acid at 10-50 mM, not reversible by addition of Mg2+ | Homo sapiens | |
Zn2+ | 33.7% of maximal activity with 0.1 mM denaturated DNA, 65.2% with 0.5 mM polydeoxythymidylic acid as substrate, noncompetitive inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
denaturated DNA | - |
Homo sapiens | |
0.02 | - |
polydeoxythymidylic acid | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | less than 1% of maximal activity without Mg2+, maximal activity at 0.5 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + H2O | Homo sapiens | - |
5'-phosphomononucleotides + 5'-phosphooligonucleotides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
KB cell | pharyngal carcinoma cell line | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.01 | - |
purified enzyme, polydeoxythymidylic acid as substrate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
denatured DNA + H2O | - |
Homo sapiens | ? | - |
? | |
DNA + H2O | - |
Homo sapiens | 5'-phosphomononucleotides + 5'-phosphooligonucleotides | - |
? | |
dsDNA + H2O | - |
Homo sapiens | 5'-phosphomononucleotides + 5'-phosphooligonucleotides | - |
? | |
polydeoxyadenylic acid + H2O | - |
Homo sapiens | 5'-dAMP + 5'-phosphooligonucleotides | - |
? | |
polydeoxycytosylic acid + H2O | only little degradation | Homo sapiens | 5'-dCMP + 5'-phosphooligonucleotides | - |
? | |
polydeoxyguanylic acid + H2O | - |
Homo sapiens | 5'-dGMP + 5'-phosphooligonucleotides | - |
? | |
polydeoxythymidylic acid + H2O | - |
Homo sapiens | 5'-dTMP + 5'-phosphooligonucleotides | - |
? | |
polyuridylic acid + H2O | 80% of activity with polydeoxythymidylic acid as substrate | Homo sapiens | 5'-UMP + 5'-phosphooligonucleotides | - |
? | |
ssDNA + H2O | - |
Homo sapiens | 5'-phosphomononucleotides + 5'-phosphooligonucleotides | no detectable 5'-phospho mononucleotides, most 5'-phospho tetranucleotides | ? |
Synonyms | Comment | Organism |
---|---|---|
KB endonuclease | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
40% loss of activity with polyuridylic acid or polydeoxythymidylic acid as substrate after heating of the enzyme fraction for 5 min | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.2 | - |
with denaturated DNA and polydeoxythymidylic acid as substrate | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 10.5 | 12.3% of maximal activity at pH 4.5, 43.3% at pH 10.5 | Homo sapiens |