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Literature summary for 3.1.4.16 extracted from

  • Anderson, B.M.; Kahn, D.W.; Anderson, C.D.
    Studies of the 2:3-cyclic nucleotide phosphodiesterase of Haemophilus influenzae (1985), J. Gen. Microbiol., 131, 2041-2045.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2'-AMP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
3',5'-cAMP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
5'-ADP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
5'-AMP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
5'-ATP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
5'-CMP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
5'-GMP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
5'-UMP 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
adenosine 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
cytidine 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
guanosine 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae
uridine 2',3'-cyclic nucleotide phosphodiesterase activity Haemophilus influenzae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.022
-
bis(p-nitrophenyl)phosphate
-
Haemophilus influenzae
0.033
-
p-Nitrophenyl phenylphosphonate
-
Haemophilus influenzae
0.167
-
thymidine p-nitrophenyl phosphate
-
Haemophilus influenzae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
79000
-
gel filtration Haemophilus influenzae

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-

Storage Stability

Storage Stability Organism
4°C or -12°C, stable Haemophilus influenzae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic 2',3'-AMP + H2O
-
Haemophilus influenzae 3'-AMP formation of adenosine without accumulation of 3'-AMP ?
di-p-nitrophenyl phosphate + H2O
-
Haemophilus influenzae p-nitrophenol + p-nitrophenyl phosphate
-
?
p-nitrophenyl phenylphosphonate + H2O
-
Haemophilus influenzae ?
-
?
thymidine p-nitrophenyl phosphate + H2O
-
Haemophilus influenzae thymidine + p-nitrophenyl phosphate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
denaturation above Haemophilus influenzae
60
-
half-life: 12.2 min Haemophilus influenzae