Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | activation by suggested binding to PDE5 GAF domain | Homo sapiens | |
Escherichia coli stable toxin | possibly due to an increase in cGMP resulting from stable toxin treatment | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
splice variants PDE5A1 and PDE5A2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil citrate | inhibition of PDE5 activity in the intestine, which might occur during sildenafil citrate ingestion, could result in a transitory diarrhoe | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
105000 | - |
2 * 105000, immunoblot | Homo sapiens |
200000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | Homo sapiens | - |
guanosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O76074 | splice variants PDE5A1 and PDE5A2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation presumably by protein kinase A or protein kinase G | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cecum | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
duodenum | - |
Homo sapiens | - |
ileum | - |
Homo sapiens | - |
jejunum | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
T-84 cell | colonic T84 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | guanosine 5'-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 105000, immunoblot | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
cGMP-binding cGMP-specific phosphodiesterase | - |
Homo sapiens |
PDE5 | - |
Homo sapiens |