Literature summary for 3.1.4.35 extracted from

Senzaki, H.; Smith, C.J.; Juang, G.J.; Isoda, T.; Mayer, S.P.; Ohler, A.; Paolocci, N.; Tomaselli, G.F.; Hare, J.M.; Kass, D.A.
Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure (2001), FASEB J., 15, 1718-1726.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(4-(4-[2-ethyl-phenylamino)-methylene]-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoic acid	0.00001 mM, 50% inhibition	Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
guanosine 3',5'-cyclic phosphate + H2O	Canis lupus familiaris	-	guanosine 5'-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	whole myocardium from failing hearts have 50% lower PDE5A expression and 30% less total and EMD82639-inhibitable cGMP-PDE activity	Canis lupus familiaris	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
guanosine 3',5'-cyclic phosphate + H2O	-	Canis lupus familiaris	guanosine 5'-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PDE5A	-	Canis lupus familiaris
phosphodiesterase 5 (cGMP-specific)	-	Canis lupus familiaris

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Release 2023.1 (January 2023)