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Literature summary for 3.1.6.18 extracted from

  • Shaklee, P.N.; Glaser, J.H.; Conrad, H.E.
    A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans (1985), J. Biol. Chem., 260, 9146-9149.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
SO42- product inhibition Gallus gallus
SO42- product inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Gallus gallus 5764
-
lysosome
-
Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
19500
-
x * 47000 + x * 19500, enzyme from liver, SDS-PAGE Homo sapiens
47000
-
x * 47000 + x * 19500, enzyme from liver, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast cell culture Homo sapiens
-
skin fibroblast cell-lines from normal and Hunter's disease, i.e. idurono 2-sulfatase deficient individuals Homo sapiens
-
tibial chondrocyte
-
Gallus gallus
-
tibial chondrocyte embryonal, cell culture Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate + H2O i.e. GSMS Gallus gallus D-glucuronic acid 2,5-anhydro-D-mannitol 6-sulfate + SO42-
-
?
D-glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate + H2O i.e. GSMS Homo sapiens D-glucuronic acid 2,5-anhydro-D-mannitol 6-sulfate + SO42-
-
?
D-glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate + H2O enzyme removes ester sulfate from 2-position Gallus gallus D-glucuronic acid 2,5-anhydro-D-mannitol 6-sulfate + SO42-
-
?
D-glucuronic acid 2-sulfate-2,5-anhydro-D-mannitol 6-sulfate + H2O enzyme removes ester sulfate from 2-position Homo sapiens D-glucuronic acid 2,5-anhydro-D-mannitol 6-sulfate + SO42-
-
?
D-glucuronic acid 2-sulfate-2,5-anhydro-D-talitol 6-sulfate + H2O i.e. GSTS Gallus gallus D-glucuronic acid 2,5-anhydro-D-talitol 6-sulfate + SO42-
-
?
D-glucuronic acid 2-sulfate-2,5-anhydro-D-talitol 6-sulfate + H2O i.e. GSTS Homo sapiens D-glucuronic acid 2,5-anhydro-D-talitol 6-sulfate + SO42-
-
?
additional information no hydrolysis of iduronate 2-sulfate residues Gallus gallus ?
-
?
additional information no hydrolysis of iduronate 2-sulfate residues Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 47000 + x * 19500, enzyme from liver, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4
-
-
Gallus gallus

pH Range

pH Minimum pH Maximum Comment Organism
3 4.9 about 90% of maximal activity at pH 3 and about half-maximal activity at pH 4.9 Gallus gallus