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Literature summary for 3.1.8.1 extracted from
- Differences in the kinetic properties, effect of calcium and sensitivity to inhibitors of paraoxon hydrolase activity in rat plasma and microsomal fraction from rat liver (1994), Biochem. Pharmacol., 48, 1559-1568.
General Stability
| General Stability | Organism |
|---|---|
| loss of activity after dialysis | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus |  |
| Co2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| EDTA | activity restored by addition of Ca2+; plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| Hg2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| La3+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| Mg2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| Mn2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| p-hydroxymercuribenzoate | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
| Zn2+ | plasma enzyme more resistant than liver enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | essential activator of rat plasma enzyme, nonessential activator of liver microsomal enzyme | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| paraoxon + H2O | - |
Rattus norvegicus | diethylphosphate + 4-nitrophenol | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
rat plasma enzyme is more stable to heat inactivation than rat liver microsomal enzyme, no loss of activity in human serum after 3 days and 33% after 5 days | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | - |
Rattus norvegicus |
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