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Literature summary for 3.2.1.118 extracted from

  • Shim, S.M.; Kwon, H.
    Metabolites of amygdalin under simulated human digestive fluids (2010), Int. J. Food Sci. Nutr., 61, 770-779.
    View publication on PubMed
Search for more literature for 3.2.1.118

Application

Application Comment Organism
diagnostics evaluating intestinal absorption of amygdalin or prunasin, by estimating its transfer across the mucosal border as well as its uptake into the intestinal tissue, for judgement of toxication rusks, overview. Use of the enzyme in an in vitro digestion model with the Caco-2 cell to estimate the human oral bioavailability of cyanogenic compounds from food or plants, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prunasin + H2O Homo sapiens prunasin is taken up in the small intestine and decomposed by beta-glucosidase into glucose and mandelonitrile, which is further hydrolyzed to benzaldehyde and hydrogen cyanide. Amygdalin, the precursor of prunasin, is a toxic component and can cause fatal cyanide poisonings, chronic toxicity, and death D-mandelonitrile + beta-D-glucose
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell TC7 clone Homo sapiens
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digestive juice
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 Homo sapiens
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small intestine use of a simulated in vitro salivary-gastric-small intestinal digestion model system Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prunasin + H2O prunasin is taken up in the small intestine and decomposed by beta-glucosidase into glucose and mandelonitrile, which is further hydrolyzed to benzaldehyde and hydrogen cyanide. Amygdalin, the precursor of prunasin, is a toxic component and can cause fatal cyanide poisonings, chronic toxicity, and death Homo sapiens D-mandelonitrile + beta-D-glucose
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prunasin + H2O substrate and product determination in the in vitro system by mass spectrometry, method, overview Homo sapiens D-mandelonitrile + beta-D-glucose
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