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Literature summary for 3.2.1.18 extracted from
- Properties of sialidase isolated from Actinomyces viscosus DSM 43798 (1989), Biol. Chem. Hoppe-Seyler, 370, 435-443.
General Stability
| General Stability | Organism |
|---|---|
| labile towards freezing and thrawing | Actinomyces viscosus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid | - |
Actinomyces viscosus |  |
| Hg2+ | - |
Actinomyces viscosus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid | - |
Actinomyces viscosus | |
| 3.3 | - |
sialyl-alpha-2,6-lactose | - |
Actinomyces viscosus | |
| 4.9 | - |
sialyl-alpha-2,3-lactose | - |
Actinomyces viscosus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell associated | - |
Actinomyces viscosus | - |
- |
| extracellular | - |
Actinomyces viscosus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 180000 | - |
gel filtration | Actinomyces viscosus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha1-acid glycoprotein + H2O | Actinomyces viscosus | - |
? | - |
? | |
| colominic acid + H2O | Actinomyces viscosus | - |
? | - |
? | |
| fetuin + H2O | Actinomyces viscosus | - |
? | - |
? | |
| ganglioside GD1a + H2O | Actinomyces viscosus | - |
? | - |
? | |
| N-acetylneuraminic acid-alpha-2,3-lactose + H2O | Actinomyces viscosus | - |
? | - |
? | |
| N-acetylneuraminic acid-alpha-2,6-lactose + H2O | Actinomyces viscosus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Actinomyces viscosus | - |
DSM 43798 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Actinomyces viscosus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 680 | - |
- |
Actinomyces viscosus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 0.1 M acetate buffer, pH 5 | Actinomyces viscosus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O | - |
Actinomyces viscosus | 4-methylumbelliferone + N-acetylneuraminic acid | - |
? | |
| alpha1-acid glycoprotein + H2O | - |
Actinomyces viscosus | ? | - |
? | |
| colominic acid + H2O | - |
Actinomyces viscosus | ? | - |
? | |
| fetuin + H2O | - |
Actinomyces viscosus | ? | - |
? | |
| ganglioside GD1a + H2O | - |
Actinomyces viscosus | ? | - |
? | |
| N-acetylneuraminic acid-alpha-2,3-lactose + H2O | - |
Actinomyces viscosus | N-acetylneuraminic acid + lactose | - |
? | |
| N-acetylneuraminic acid-alpha-2,3-lactose + H2O | - |
Actinomyces viscosus | ? | - |
? | |
| N-acetylneuraminic acid-alpha-2,6-lactose + H2O | - |
Actinomyces viscosus | N-acetylneuraminic acid + lactose | - |
? | |
| N-acetylneuraminic acid-alpha-2,6-lactose + H2O | - |
Actinomyces viscosus | ? | - |
? | |
| sialyl-alpha-2,3-lactose + H2O | - |
Actinomyces viscosus | ? | - |
? | |
| sialyl-alpha-2,6-lactose + H2O | - |
Actinomyces viscosus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | SDS-PAGE | Actinomyces viscosus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Actinomyces viscosus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 10 | 60 | - |
Actinomyces viscosus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
- |
Actinomyces viscosus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 3 | 6 | - |
Actinomyces viscosus |
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