Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.20 extracted from

  • Hari Babu, T.; Rama Subba Rao, V.; Tiwari, A.K.; Suresh Babu, K.; Srinivas, P.V.; Ali, A.Z.; Madhusudana Rao, J.
    Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 1659-1662.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
Saccharomyces cerevisiae
5,7-dihydroxy-2-phenyl-4H-chromen-4-one from hexane extracts of the Indian herb Oroxylum indicum Saccharomyces cerevisiae
5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
-
Rattus norvegicus
5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
-
Saccharomyces cerevisiae
5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
-
Rattus norvegicus
5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
-
Saccharomyces cerevisiae
5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
-
Rattus norvegicus
5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
-
Saccharomyces cerevisiae
acarbose
-
Rattus norvegicus
baicalein i.e. 5,6,7-trihydroxy flavone, from hexane extracts of the Indian herb Oroxylum indicum Rattus norvegicus
baicalein i.e. 5,6,7-trihydroxy flavone, from hexane extracts of the Indian herb Oroxylum indicum Saccharomyces cerevisiae
chrysin from hexane extracts of the Indian herb Oroxylum indicum Rattus norvegicus
additional information no inhibition by acarbose Saccharomyces cerevisiae
oroxylin A from hexane extracts of the Indian herb Oroxylum indicum Rattus norvegicus
oroxylin A from hexane extracts of the Indian herb Oroxylum indicum Saccharomyces cerevisiae
tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
-
Rattus norvegicus
tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
maltose + H2O Rattus norvegicus
-
alpha-D-glucose + D-glucose
-
?
maltose + H2O Saccharomyces cerevisiae
-
alpha-D-glucose + D-glucose
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-glucopyranoside + H2O
-
Rattus norvegicus 4-nitrophenol + alpha-D-glucose
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
-
Saccharomyces cerevisiae 4-nitrophenol + alpha-D-glucose
-
?
maltose + H2O
-
Rattus norvegicus alpha-D-glucose + D-glucose
-
?
maltose + H2O
-
Saccharomyces cerevisiae alpha-D-glucose + D-glucose
-
?

Synonyms

Synonyms Comment Organism
maltase
-
Rattus norvegicus
maltase
-
Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.5
-
baicalein
-
Rattus norvegicus
0.5
-
baicalein
-
Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0064
-
-
Rattus norvegicus acarbose
0.0354
-
-
Rattus norvegicus 5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
0.0493
-
-
Saccharomyces cerevisiae (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
0.0507
-
-
Rattus norvegicus 5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
0.075
-
-
Rattus norvegicus tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
0.076
-
-
Rattus norvegicus 5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
0.08 4
-
Saccharomyces cerevisiae tert-butyl 4-[(5,7-dihydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)methyl]piperazine-1-carboxylate
0.099
-
-
Saccharomyces cerevisiae 5,7-dihydroxy-6-methoxy-8-[(4-methylpiperazin-1-yl)methyl]-2-phenyl-4H-chromen-4-one
0.124
-
-
Saccharomyces cerevisiae oroxylin A
0.135
-
-
Rattus norvegicus oroxylin A
0.15
-
-
Saccharomyces cerevisiae 5,7-dihydroxy-6-methoxy-8-(morpholin-4-ylmethyl)-2-phenyl-4H-chromen-4-one
0.167
-
-
Saccharomyces cerevisiae 5,7-dihydroxy-6-methoxy-2-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
0.203
-
-
Saccharomyces cerevisiae baicalein
0.214
-
-
Rattus norvegicus baicalein
0.371
-
-
Saccharomyces cerevisiae 5,7-dihydroxy-2-phenyl-4H-chromen-4-one
0.375
-
-
Rattus norvegicus chrysin