Literature summary for 3.2.1.20 extracted from

Kim, K.Y.; Nam, K.A.; Kurihara, H.; Kim, S.M.
Potent alpha-glucosidase inhibitors purified from the red alga Grateloupia elliptica (2008), Phytochemistry, 69, 2820-2825.

Search for more literature for 3.2.1.20

Application

Application	Comment	Organism
medicine	one therapeutic approach for decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of alpha-glucosidase. Bromophenols of Grateloupia elliptica have potential as natural nutraceuticals to prevent diabetes mellitus because of their high alpha-glucosidase inhibitory activity	Rattus norvegicus
medicine	one therapeutic approach for decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of alpha-glucosidase. Bromophenols of Grateloupia elliptica have potential as natural nutraceuticals to prevent diabetes mellitus because of their high alpha-glucosidase inhibitory activity	Saccharomyces cerevisiae
medicine	one therapeutic approach for decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of alpha-glucosidase. Bromophenols of Grateloupia elliptica have potential as natural nutraceuticals to prevent diabetes mellitus because of their high alpha-glucosidase inhibitory activity	Geobacillus stearothermophilus

Inhibitors

Inhibitors	Comment	Organism	Structure
2,4,6-tribromophenol	purified from the red alga Grateloupia elliptica	Geobacillus stearothermophilus
2,4,6-tribromophenol	purified from the red alga Grateloupia elliptica	Rattus norvegicus
2,4,6-tribromophenol	purified from the red alga Grateloupia elliptica	Saccharomyces cerevisiae
2,4-Dibromophenol	purified from the red alga Grateloupia elliptica	Geobacillus stearothermophilus
2,4-Dibromophenol	purified from the red alga Grateloupia elliptica	Rattus norvegicus
2,4-Dibromophenol	purified from the red alga Grateloupia elliptica	Saccharomyces cerevisiae
acarbose	-	Rattus norvegicus
additional information	compounds with alpha-glucosidase inhibitory activity are preliminarily screened and purified from ten different seaweeds (two green, four brown, and four red). The alpha-glucosidase inhibitory activity of the MeOH H2O (4:1, v/v) extract of Polyopes lancifolia at 5 mg/ml is highest at 52.2%, followed by Grateloupia elliptica (42.0%), Sargassum thunbergii (24.3%), and Grateloupia. lanceolata (22.0%) in decreasing order	Saccharomyces cerevisiae
voglibose	-	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Na+	inhibitory assay is stopped by adding 0.1 M Na2CO3	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Geobacillus stearothermophilus	-	-	-
Rattus norvegicus	-	-	-
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl alpha-D-glucopyranoside + H2O	-	Saccharomyces cerevisiae	4-nitrophenol + alpha-D-glucopyranose	-	?
maltose + H2O	-	Rattus norvegicus	alpha-D-glucose + D-glucose	-	?

Synonyms

Synonyms	Comment	Organism
alpha-glucosidase	-	Saccharomyces cerevisiae
alpha-glucosidase	-	Geobacillus stearothermophilus
intestinal alpha-glucosidase	-	Rattus norvegicus
intestinal maltase	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0152	-	2,4,6-tribromophenol	mixed inhibition	Saccharomyces cerevisiae
0.0921	-	2,4-Dibromophenol	mixed inhibition	Saccharomyces cerevisiae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00004	-	-	Rattus norvegicus	voglibose
0.00008	-	-	Rattus norvegicus	acarbose
0.0048	-	-	Rattus norvegicus	2,4-Dibromophenol
0.005	-	-	Rattus norvegicus	2,4,6-tribromophenol
0.0603	-	-	Saccharomyces cerevisiae	2,4,6-tribromophenol
0.1104	-	-	Saccharomyces cerevisiae	2,4-Dibromophenol
0.1303	-	-	Geobacillus stearothermophilus	2,4,6-tribromophenol
0.2303	-	-	Geobacillus stearothermophilus	2,4-Dibromophenol

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Release 2023.1 (January 2023)