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Literature summary for 3.2.1.21 extracted from
- Galactosylsphingosine inhibition of the broad-specificity cytosolic beta-glucosidase of human liver (1985), Arch. Biochem. Biophys., 236, 669-676.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| galactosylsphingosine | mixed-type inhibition, substrate-dependent | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
4-methylumbelliferyl-beta-D-arabinopyranoside | - |
Homo sapiens | |
| 0.06 | - |
4-methylumbelliferyl-beta-D-glucopyranoside | - |
Homo sapiens | |
| 0.08 | - |
4-methylumbelliferyl-beta-D-xylopyranoside | - |
Homo sapiens | |
| 0.15 | - |
4-methylumbelliferyl-beta-D-galactopyranoside | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, chromatography steps | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 7.87 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-beta-D-arabinopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-arabinopyranose | - |
? | |
| 4-methylumbelliferyl-beta-D-galactopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-galactopyranose | - |
? | |
| 4-methylumbelliferyl-beta-D-glucoside + H2O | presence of sphingolipid binding site, possible role in glycosphingolipid metabolism | Homo sapiens | 4-methylumbelliferone + beta-D-glucose | - |
? | |
| 4-methylumbelliferyl-beta-D-xylopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-xylopyranose | - |
? | |
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