Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.21 extracted from

  • Arcelli, A.; Balducci, D.; Porzi, G.; Sandri, M.
    Chiral piperazine-2,5-dione derivatives as effective alpha-glucosidase inhibitors. Part 4 (2010), Chem. Biodivers., 7, 225-228.
    View publication on PubMed
Search for more literature for 3.2.1.21

Application

Application Comment Organism
medicine potential target for antidiabetic therapy Prunus dulcis

Inhibitors

Inhibitors Comment Organism Structure
(1S,5S)-3-methylidene-6,8-bis[(1S)-1-phenylethyl]-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Prunus dulcis
(2S,5S)-2-benzyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Prunus dulcis
(2S,5S)-2-methyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Prunus dulcis
(2S,5S)-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Prunus dulcis

Organism

Organism UniProt Comment Textmining
Prunus dulcis
-
-
-

Synonyms

Synonyms Comment Organism
beta-glucosidase
-
 Prunus dulcis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Prunus dulcis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.85
-
 assay at Prunus dulcis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.45
-
 (1S,5S)-3-methylidene-6,8-bis[(1S)-1-phenylethyl]-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Prunus dulcis
0.535
-
 (2S,5S)-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Prunus dulcis
0.58
-
 (2S,5S)-2-benzyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Prunus dulcis
2.2
-
 (2S,5S)-2-methyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Prunus dulcis