Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.21 extracted from

  • Li, K.Y.; Jiang, J.; Witte, M.D.; Kallemeijn, W.W.; Donker-Koopman, W.E.; Boot, R.G.; Aerts, J.M.; Codee, J.D.; van der Marel, G.A.; Overkleeft, H.S.
    Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors (2014), Org. Biomol. Chem., 12, 7786-7791.
    View publication on PubMed
Search for more literature for 3.2.1.21

Inhibitors

Inhibitors Comment Organism Structure
7-(N-benzoyl)-cyclophellitol aziridine
-
 Homo sapiens
7-(N-butylsulfonyl)-cyclophellitol aziridine
-
 Homo sapiens
7-(N-pentoyl)-cyclophellitol aziridine
-
 Homo sapiens
7-pentylcyclophellitol aziridine
-
 Homo sapiens
cyclophellitol potent inhibitor Homo sapiens
cyclophellitol aziridine
-
 Homo sapiens
cyclophellitol thiirane
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl beta-D-glucopyranoside + H2O
-
 Homo sapiens 4-nitrophenol + D-glucopyranose
-
 ?

Synonyms

Synonyms Comment Organism
GBA isoform Homo sapiens
GBA2 isoform Homo sapiens
GBA3 isoform Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000017
-
 isoform GBA, in 150 mM McIlvaine buffer, pH 5.2, at 37°C Homo sapiens 7-pentylcyclophellitol aziridine
0.000055
-
 isoform GBA2, in 150 mM McIlvaine buffer, pH 5.8, at 37°C Homo sapiens 7-(N-benzoyl)-cyclophellitol aziridine
0.00007
-
 isoform GBA, in 150 mM McIlvaine buffer, pH 5.2, at 37°C Homo sapiens 7-(N-pentoyl)-cyclophellitol aziridine
0.0002
-
 isoform GBA2, in 150 mM McIlvaine buffer, pH 5.8, at 37°C Homo sapiens 7-(N-pentoyl)-cyclophellitol aziridine
0.0003
-
 isoform GBA3, in 150 mM McIlvaine buffer, pH 6.0, at 37°C Homo sapiens 7-(N-butylsulfonyl)-cyclophellitol aziridine
0.0003
-
 isoform GBA2, in 150 mM McIlvaine buffer, pH 5.8, at 37°C Homo sapiens 7-(N-butylsulfonyl)-cyclophellitol aziridine
0.00035
-
 isoform GBA, in 150 mM McIlvaine buffer, pH 5.2, at 37°C Homo sapiens cyclophellitol
0.0004
-
 isoform GBA2, in 150 mM McIlvaine buffer, pH 5.8, at 37°C Homo sapiens cyclophellitol aziridine
0.0005
-
 isoform GBA3, in 150 mM McIlvaine buffer, pH 6.0, at 37°C Homo sapiens 7-(N-pentoyl)-cyclophellitol aziridine
0.0005
-
 isoform GBA, in 150 mM McIlvaine buffer, pH 5.2, at 37°C Homo sapiens cyclophellitol aziridine
0.0007
-
 isoform GBA3, in 150 mM McIlvaine buffer, pH 6.0, at 37°C Homo sapiens 7-pentylcyclophellitol aziridine
0.0007
-
 isoform GBA2, in 150 mM McIlvaine buffer, pH 5.8, at 37°C Homo sapiens 7-pentylcyclophellitol aziridine
0.0014
-
 isoform GBA, in 150 mM McIlvaine buffer, pH 5.2, at 37°C Homo sapiens 7-(N-benzoyl)-cyclophellitol aziridine
0.002
-
 isoform GBA2, in 150 mM McIlvaine buffer, pH 5.8, at 37°C Homo sapiens cyclophellitol
0.0025
-
 isoform GBA, in 150 mM McIlvaine buffer, pH 5.2, at 37°C Homo sapiens 7-(N-butylsulfonyl)-cyclophellitol aziridine
0.02
-
 isoform GBA3, in 150 mM McIlvaine buffer, pH 6.0, at 37°C Homo sapiens 7-(N-benzoyl)-cyclophellitol aziridine
0.1
-
 IC50 above 0.1 mM, isoform GBA3, in 150 mM McIlvaine buffer, pH 6.0, at 37°C Homo sapiens cyclophellitol
0.1
-
 IC50 above 0.1 mM, isoform GBA3, in 150 mM McIlvaine buffer, pH 6.0, at 37°C Homo sapiens cyclophellitol aziridine
0.1
-
 IC50 above 0.1 mM, GBA3, in 150 mM McIlvaine buffer, pH 6.0, at 37°C Homo sapiens cyclophellitol thiirane
0.1
-
 IC50 above 0.1 mM, isoform GBA, in 150 mM McIlvaine buffer, pH 5.2, at 37°C Homo sapiens cyclophellitol thiirane
0.1
-
 IC50 above 0.1 mM, isoform GBA2, in 150 mM McIlvaine buffer, pH 5.8, at 37°C Homo sapiens cyclophellitol thiirane