Application | Comment | Organism |
---|---|---|
medicine | enzyme inhibitors are very effective in controlling blood glucose levels, and thus are lead candidates for the treatment of type 2 diabetes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S,3S,4R,5R)-1-((1S,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydro-1H-selenophenium-1-yl)-2,4,5,7-tetrahydroxyheptan-3-yl sulfate | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
(2S,3S,4R,5R)-1-((1S,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydro-1H-thiophenium-1-yl)-2,4,5,7-tetrahydroxyheptan-3-yl sulfate | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3R,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episelenoniumylidene]-D-arabinitol | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3R,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episulfoniumylidene]-D-arabinitol | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3R,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]iminonium]-D-arabinitol | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3S,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episelenoniumylidene]-D-arabinitol | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3S,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episulfoniumylidene]-D-arabinitol | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3S,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]iminonium]-D-arabinitol | a structure analogue of salacinol, synthesis, overview | Homo sapiens | |
blintol | a selenium analogue of salacinol, is very effective in controlling blood glucose levels in rats after a carbohydrate meal, thus providing a lead candidate for the treatment of type 2 diabetes, synthesis, overview | Homo sapiens | |
kotalanol | isolated from the roots and stems of the plant Salacia reticulata, contains an intriguing inner-salt sulfonium-sulfate structure, inhibition of glucosidases by salacinol and kotalanol is due to their ability to mimic both the shape and charge of the oxacarbenium-ion-like transition state involved in the enzymatic reactions | Homo sapiens | |
additional information | ghavamiol, a nitrogen analogue of salacinol, is inactive as inhibitor | Homo sapiens | |
salacinol | isolated from the roots and stems of the plant Salacia reticulata, contains an intriguing inner-salt sulfonium-sulfate structure, inhibition of glucosidases by salacinol is due to their ability to mimic both the shape and charge of the oxacarbenium-ion-like transition state involved in the enzymatic reactions, the compound is capable of attenuating the spike in blood glucose levels | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
starch + H2O | Homo sapiens | one of the key intestinal enzymes involved in the breakdown of glucose oligosaccharides in the small intestine | beta-D-glucose + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-nitrophenol + beta-D-glucose | - |
? | |
starch + H2O | - |
Homo sapiens | beta-D-glucose + ? | - |
? | |
starch + H2O | one of the key intestinal enzymes involved in the breakdown of glucose oligosaccharides in the small intestine | Homo sapiens | beta-D-glucose + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
maltase glucoamylase | - |
Homo sapiens |
MGA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
1,4-dideoxy-1,4-[[(2S,3R,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episelenoniumylidene]-D-arabinitol | pH 6.5, 37°C | Homo sapiens | |
0.0001 | - |
1,4-dideoxy-1,4-[[(2S,3S,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episelenoniumylidene]-D-arabinitol | pH 6.5, 37°C | Homo sapiens | |
0.00014 | - |
(2S,3S,4R,5R)-1-((1S,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydro-1H-selenophenium-1-yl)-2,4,5,7-tetrahydroxyheptan-3-yl sulfate | pH 6.5, 37°C | Homo sapiens | |
0.00015 | - |
1,4-dideoxy-1,4-[[(2S,3R,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episulfoniumylidene]-D-arabinitol | pH 6.5, 37°C | Homo sapiens | |
0.00017 | - |
1,4-dideoxy-1,4-[[(2S,3S,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]episulfoniumylidene]-D-arabinitol | pH 6.5, 37°C | Homo sapiens | |
0.00019 | - |
salacinol | pH 6.5, 37°C | Homo sapiens | |
0.00049 | - |
blintol | pH 6.5, 37°C | Homo sapiens | |
0.00065 | - |
(2S,3S,4R,5R)-1-((1S,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydro-1H-thiophenium-1-yl)-2,4,5,7-tetrahydroxyheptan-3-yl sulfate | pH 6.5, 37°C | Homo sapiens | |
0.008 | - |
1,4-dideoxy-1,4-[[(2S,3S,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]iminonium]-D-arabinitol | pH 6.5, 37°C | Homo sapiens | |
0.035 | - |
1,4-dideoxy-1,4-[[(2S,3R,4R,5S)-2,4,5,6-tetrahydroxy-3-(sulfoxy)hexyl]iminonium]-D-arabinitol | pH 6.5, 37°C | Homo sapiens |