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Literature summary for 3.2.1.31 extracted from

  • Schreiber, R.; Taschler, U.; Wolinski, H.; Seper, A.; Tamegger, S.N.; Graf, M.; Kohlwein, S.D.; Haemmerle, G.; Zimmermann, R.; Zechner, R.; Lass, A.
    Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver (2009), J. Lipid Res., 50, 2514-2523.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.31

Cloned(Commentary)

Cloned (Comment) Organism
expression of red fluorescent protein, RFP, fusion Gus in COS-7 cells, coexpression with GFP-tagged esterase 22 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the beta-glucuronidase forms a complex with esterase 22 in the liver. Gus colocalizes with Es22 at the endoplasmic reticulum but does not affect its RE hydrolase activity Mus musculus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the beta-glucuronidase forms a complex with esterase 22 in the liver. Gus colocalizes with Es22 at the endoplasmic reticulum but does not affect its retinoyl ester hydrolase activity ?
-
 ?
retinyl-beta-glucuronide + H2O Mus musculus
-
 retinol + D-glucuronide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 adult male C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the beta-glucuronidase forms a complex with esterase 22 in the liver. Gus colocalizes with Es22 at the endoplasmic reticulum but does not affect its retinoyl ester hydrolase activity Mus musculus ?
-
 ?
retinyl-beta-glucuronide + H2O
-
 Mus musculus retinol + D-glucuronide
-
 ?

Synonyms

Synonyms Comment Organism
GUS
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at, recombinant RFP-tagged enzyme Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at, recombinant RFP-tagged enzyme Mus musculus

General Information

General Information Comment Organism
physiological function beta-glucuronidase forms a complex with esterase 22 in the liver, both esterase Es22 and Gus play a role in liver retinoid metabolism Mus musculus