Literature summary for 3.2.1.31 extracted from

Kunihiro, A.G.; Luis, P.B.; Brickey, J.A.; Frye, J.B.; Chow, H.S.; Schneider, C.; Funk, J.L.
beta-Glucuronidase catalyzes deconjugation and activation of curcumin-glucuronide in bone (2019), J. Nat. Prod., 82, 500-509 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
saccharolactone	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
curcumin-beta-D-glucuronide + H2O	Mus musculus	curcumin, despite low systemic bioavailability, may be enzymatically activated (deconjugated) within GUSB-enriched bone to exert protective effects, a metabolic process that can also contribute to bone-protective effects of other highly glucuronidated dietary polyphenols	curcumin + beta-D-glucuronic acid	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P12265	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood serum	-	Mus musculus	-
hematopoietic cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl beta-D-glucuronide + H2O	-	Mus musculus	4-methylumbelliferone + beta-D-glucuronic acid	-	?
curcumin beta-D-glucuronide + H2O	-	Mus musculus	curcumin + beta-D-glucuronic acid	-	?
curcumin-beta-D-glucuronide + H2O	curcumin, despite low systemic bioavailability, may be enzymatically activated (deconjugated) within GUSB-enriched bone to exert protective effects, a metabolic process that can also contribute to bone-protective effects of other highly glucuronidated dietary polyphenols	Mus musculus	curcumin + beta-D-glucuronic acid	-	?

Synonyms

Synonyms	Comment	Organism
GusB	-	Mus musculus

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Release 2023.1 (January 2023)