Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phlorizin | competitive inhibition of lactase activity | Homo sapiens | |
phlorizin | competitive inhibition of lactase activity, Ki: 0.37 mM | Sus scrofa | |
Tris(hydroxymethyl)aminomethane | - |
Homo sapiens | |
Tris(hydroxymethyl)aminomethane | competitive inhibition of lactase activity, Ki: 5.1 mM | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5.1 | - |
4-O-beta-D-galactopyranosyl-D-glucopyranoside | slightly higher catalytic efficiency than for the human enzyme | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microvillus | - |
Homo sapiens | 5902 | - |
microvillus | - |
Sus scrofa | 5902 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
160000 | - |
2 * 160000, SDS-PAGE | Sus scrofa |
320000 | - |
gel filtration, amphiphilic form | Homo sapiens |
320000 | - |
gel filtration, amphiphilic form | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O | Homo sapiens | - |
D-galactose + beta-D-glucose | - |
? | |
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O | Sus scrofa | two enzymatic activities, one for lactose- and one for phlorizin-and lactose-hydrolysis | D-galactose + beta-D-glucose | - |
? | |
4-O-beta-D-glucopyranosyl-D-glucose + H2O | Homo sapiens | cellobiose | beta-D-glucose + D-glucose | - |
? | |
4-O-beta-D-glucopyranosyl-D-glucose + H2O | Sus scrofa | cellobiose | beta-D-glucose + D-glucose | - |
? | |
6-O-beta-D-glucopyranosyl-D-glucose + H2O | Sus scrofa | low activity | beta-D-glucose + D-glucose | - |
? | |
6-O-beta-D-glucopyranosyl-D-glucose + H2O | Homo sapiens | gentiobiose | beta-D-glucose + D-glucose | - |
? | |
6-O-beta-D-glucopyranosyl-D-glucose + H2O | Sus scrofa | gentiobiose | beta-D-glucose + D-glucose | - |
? | |
cellotetraose + H2O | Homo sapiens | considerable activity | ? + beta-D-glucose | - |
? | |
cellotetraose + H2O | Sus scrofa | considerable activity | ? + beta-D-glucose | - |
? | |
cellotriose + H2O | Homo sapiens | considerable activity | ? + beta-D-glucose | - |
? | |
cellotriose + H2O | Sus scrofa | considerable activity | ? + beta-D-glucose | - |
? | |
cellulose + H2O | Homo sapiens | very low activity | ? + beta-D-glucose | - |
? | |
cellulose + H2O | Sus scrofa | very low activity | ? + beta-D-glucose | - |
? | |
phlorizin + H2O | Homo sapiens | - |
phloretin + beta-D-glucose | - |
? | |
phlorizin + H2O | Sus scrofa | 5% of the activity of lactose hydrolysis | phloretin + beta-D-glucose | - |
? | |
phlorizin + H2O | Sus scrofa | hydrolysis located on a specific active site for phlorizin hydrolysis | phloretin + beta-D-glucose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
to homogeneity, immunoadsorbent chromatography, amphiphilic form | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | small intestine | Homo sapiens | - |
intestine | small intestine | Sus scrofa | - |
intestine | proximal jejenum | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-naphthyl-beta-D-galactopyranoside + H2O | very low activity | Sus scrofa | 2-naphthol + beta-D-galactopyranose | - |
? | |
2-nitrophenyl beta-D-galactopyranoside + H2O | - |
Homo sapiens | 2-nitrophenol + beta-D-galactose | - |
? | |
2-nitrophenyl beta-D-galactopyranoside + H2O | lower activity than for 4-nitrophenyl-beta-D-galactopyranoside | Sus scrofa | 2-nitrophenol + beta-D-galactose | - |
? | |
4-nitrophenyl beta-D-galactopyranoside + H2O | - |
Homo sapiens | 4-nitrophenol + beta-D-galactose | - |
? | |
4-nitrophenyl beta-D-galactopyranoside + H2O | - |
Sus scrofa | 4-nitrophenol + beta-D-galactose | - |
? | |
4-nitrophenyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-nitrophenol + beta-D-glucose | - |
? | |
4-nitrophenyl beta-D-glucopyranoside + H2O | - |
Sus scrofa | 4-nitrophenol + beta-D-glucose | - |
? | |
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O | - |
Homo sapiens | D-galactose + beta-D-glucose | - |
? | |
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O | two enzymatic activites, one for lactose- and one for phlorizin-and lactose-hydrolysis | Sus scrofa | D-galactose + beta-D-glucose | - |
? | |
4-O-beta-D-galactopyranosyl-D-glucopyranoside + H2O | two enzymatic activities, one for lactose- and one for phlorizin-and lactose-hydrolysis | Sus scrofa | D-galactose + beta-D-glucose | - |
? | |
4-O-beta-D-glucopyranosyl-D-glucose + H2O | cellobiose | Homo sapiens | beta-D-glucose + D-glucose | - |
? | |
4-O-beta-D-glucopyranosyl-D-glucose + H2O | cellobiose | Sus scrofa | beta-D-glucose + D-glucose | - |
? | |
6-bromonaphthyl-beta-D-galactopyranoside | very low activity | Sus scrofa | 6-bromonaphthol + beta-D-galactopyranose | - |
? | |
6-O-beta-D-glucopyranosyl-D-glucose + H2O | low activity | Sus scrofa | beta-D-glucose + D-glucose | - |
? | |
6-O-beta-D-glucopyranosyl-D-glucose + H2O | gentiobiose | Homo sapiens | beta-D-glucose + D-glucose | - |
? | |
6-O-beta-D-glucopyranosyl-D-glucose + H2O | gentiobiose | Sus scrofa | beta-D-glucose + D-glucose | - |
? | |
cellotetraose + H2O | considerable activity | Homo sapiens | ? + beta-D-glucose | - |
? | |
cellotetraose + H2O | considerable activity | Sus scrofa | ? + beta-D-glucose | - |
? | |
cellotriose + H2O | considerable activity | Homo sapiens | ? + beta-D-glucose | - |
? | |
cellotriose + H2O | considerable activity | Sus scrofa | ? + beta-D-glucose | - |
? | |
cellulose + H2O | very low activity | Homo sapiens | ? + beta-D-glucose | - |
? | |
cellulose + H2O | very low activity | Sus scrofa | ? + beta-D-glucose | - |
? | |
phenyl-beta-D-galactopyranoside + H2O | low activity | Sus scrofa | phenol + beta-D-galactopyranose | - |
? | |
phlorizin + H2O | - |
Homo sapiens | phloretin + beta-D-glucose | - |
? | |
phlorizin + H2O | 5% of the activity of lactose hydrolysis | Sus scrofa | phloretin + beta-D-glucose | - |
? | |
phlorizin + H2O | hydrolysis located on a specific active site for phlorizin hydrolysis | Sus scrofa | phloretin + beta-D-glucose | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Homo sapiens |
dimer | 2 * 160000, SDS-PAGE | Sus scrofa |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
49 | - |
lactase activity faster destroyed than phlorizin activity | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.6 | 6.2 | - |
Sus scrofa |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
3.2 | - |
little activity below | Sus scrofa |