BRENDA - Enzyme Database
show all sequences of 3.2.2.16

Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system

Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B.; Int. J. Med. Microbiol. 303, 190-200 (2013)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5'-deoxyadenosine + H2O
Staphylococcus aureus
-
5-deoxy-D-ribose + adenine
-
-
?
5'-deoxyadenosine + H2O
Staphylococcus aureus NCTC 8325
-
5-deoxy-D-ribose + adenine
-
-
?
5'-deoxyadenosine + H2O
Staphylococcus aureus RN4220
-
5-deoxy-D-ribose + adenine
-
-
?
S-adenosyl-L-homocysteine + H2O
Staphylococcus aureus
-
S-ribosyl-L-homocysteine + adenine
-
-
?
S-adenosyl-L-homocysteine + H2O
Staphylococcus aureus NCTC 8325
-
S-ribosyl-L-homocysteine + adenine
-
-
?
S-adenosyl-L-homocysteine + H2O
Staphylococcus aureus RN4220
-
S-ribosyl-L-homocysteine + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus
-
S-methyl-5-thio-D-ribose + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus
-
adenine + S-methyl-5-thio-D-ribose
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus NCTC 8325
-
S-methyl-5-thio-D-ribose + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus NCTC 8325
-
adenine + S-methyl-5-thio-D-ribose
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus RN4220
-
S-methyl-5-thio-D-ribose + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus RN4220
-
adenine + S-methyl-5-thio-D-ribose
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus NCTC 8325
-
-
-
Staphylococcus aureus RN4220
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5'-deoxyadenosine + H2O
-
727637
Staphylococcus aureus
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
-
727637
Staphylococcus aureus NCTC 8325
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
-
727637
Staphylococcus aureus RN4220
5-deoxy-D-ribose + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
-
727637
Staphylococcus aureus
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
-
727637
Staphylococcus aureus NCTC 8325
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
-
727637
Staphylococcus aureus RN4220
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus NCTC 8325
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus RN4220
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus NCTC 8325
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus RN4220
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5'-deoxyadenosine + H2O
Staphylococcus aureus
-
5-deoxy-D-ribose + adenine
-
-
?
5'-deoxyadenosine + H2O
Staphylococcus aureus NCTC 8325
-
5-deoxy-D-ribose + adenine
-
-
?
5'-deoxyadenosine + H2O
Staphylococcus aureus RN4220
-
5-deoxy-D-ribose + adenine
-
-
?
S-adenosyl-L-homocysteine + H2O
Staphylococcus aureus
-
S-ribosyl-L-homocysteine + adenine
-
-
?
S-adenosyl-L-homocysteine + H2O
Staphylococcus aureus NCTC 8325
-
S-ribosyl-L-homocysteine + adenine
-
-
?
S-adenosyl-L-homocysteine + H2O
Staphylococcus aureus RN4220
-
S-ribosyl-L-homocysteine + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus
-
S-methyl-5-thio-D-ribose + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus
-
adenine + S-methyl-5-thio-D-ribose
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus NCTC 8325
-
S-methyl-5-thio-D-ribose + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus NCTC 8325
-
adenine + S-methyl-5-thio-D-ribose
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus RN4220
-
S-methyl-5-thio-D-ribose + adenine
-
-
?
S-methyl-5'-thioadenosine + H2O
Staphylococcus aureus RN4220
-
adenine + S-methyl-5-thio-D-ribose
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5'-deoxyadenosine + H2O
-
727637
Staphylococcus aureus
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
-
727637
Staphylococcus aureus NCTC 8325
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
-
727637
Staphylococcus aureus RN4220
5-deoxy-D-ribose + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
-
727637
Staphylococcus aureus
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
-
727637
Staphylococcus aureus NCTC 8325
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
-
727637
Staphylococcus aureus RN4220
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus NCTC 8325
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus RN4220
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus NCTC 8325
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
S-methyl-5'-thioadenosine + H2O
-
727637
Staphylococcus aureus RN4220
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
the enzyme is essential for the virulence of Staphylococcus aureus. The enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production; the enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production. The enzyme is associated with Staphylococcus aureus subcutaneous abscess infection of mice
Staphylococcus aureus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the enzyme is essential for the virulence of Staphylococcus aureus. The enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production; the enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production. The enzyme is associated with Staphylococcus aureus subcutaneous abscess infection of mice
Staphylococcus aureus
Other publictions for EC 3.2.2.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732449
Bao
Pfs promotes autolysis-depende ...
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
Med. Microbiol. Immunol.
204
215-226
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
12
-
-
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2
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2
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2
-
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-
2
2
-
-
-
726595
Kim
Structural enzymology of Helic ...
Helicobacter pylori
Acta Crystallogr. Sect. D
70
177-185
2014
-
1
1
1
4
-
-
-
-
-
-
3
-
4
-
-
1
1
-
-
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
2
7
-
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3
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2
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-
5
1
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-
2
2
-
-
-
726889
Kang
Crystal structure and biochemi ...
Brucella melitensis
Biochem. Biophys. Res. Commun.
446
965-970
2014
-
-
1
1
18
-
-
25
-
-
1
2
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
25
-
-
-
-
-
-
-
-
-
1
-
1
18
-
-
-
-
25
-
-
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
25
-
-
-
-
-
-
-
-
25
25
727044
Wang
Catalytic site cooperativity i ...
Escherichia coli, Staphylococcus aureus, Vibrio cholerae
Biochemistry
53
1527-1535
2014
-
-
3
2
6
-
3
7
-
-
-
4
-
7
-
-
3
-
-
-
-
-
4
1
-
-
-
8
-
-
-
-
-
-
-
-
-
3
-
2
6
-
-
3
-
7
-
-
-
4
-
-
-
3
-
-
-
-
4
1
-
-
-
8
-
-
-
-
-
-
-
-
8
8
727555
Gao
Substrate preference of 5'-met ...
Burkholderia thailandensis
FEMS Microbiol. Lett.
339
110-116
2013
-
-
1
-
-
-
-
1
-
-
1
3
-
4
-
-
1
-
-
-
-
-
3
1
1
1
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
3
-
-
-
1
-
-
-
-
3
1
1
1
-
1
-
1
-
-
-
-
-
-
1
1
727637
Bao
Methylthioadenosine/S-adenosyl ...
Staphylococcus aureus, Staphylococcus aureus NCTC 8325, Staphylococcus aureus RN4220
Int. J. Med. Microbiol.
303
190-200
2013
-
-
-
-
-
-
-
-
-
-
-
12
-
34
-
-
-
-
-
-
-
-
12
-
-
-
-
-
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-
-
-
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-
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-
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-
-
12
-
-
-
-
-
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-
-
12
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
727008
Mishra
Crystal structures of the Heli ...
Helicobacter pylori
Biochemistry
51
9763-9772
2012
-
-
1
1
3
-
-
6
-
-
-
4
-
3
-
-
1
-
-
-
-
-
4
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
1
3
-
-
-
-
6
-
-
-
4
-
-
-
1
-
-
-
-
4
-
-
-
-
6
-
-
-
-
-
-
-
-
6
6
727159
Clinch
Transition state analogue inhi ...
Escherichia coli, Neisseria meningitidis
Bioorg. Med. Chem.
20
5181-5187
2012
-
-
-
-
-
-
34
-
-
-
-
2
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
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-
-
-
-
32
-
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-
34
32
-
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-
2
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727674
Wang
A complex of methylthioadenosi ...
Escherichia coli
J. Am. Chem. Soc.
134
1468-1470
2012
-
-
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-
1
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1
1
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2
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1
1
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-
1
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-
1
1
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1
1
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-
1
1
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-
-
-
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-
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-
-
-
728199
Cho
-
Cobalt-requiring 5'-deoxy-5'-m ...
Glycine max
J. Plant Biochem. Biotechnol.
21
113-116
2012
-
-
-
-
-
-
1
1
-
1
2
2
-
1
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1
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1
2
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2
2
1
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-
-
1
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-
1
-
1
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1
2
2
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1
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1
2
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2
2
1
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-
-
1
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-
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-
731300
Thomas
Femtomolar inhibitors bind to ...
Escherichia coli, Salmonella enterica, Vibrio cholerae
Biochemistry
51
7541-7550
2012
-
-
3
1
-
-
21
6
-
-
-
9
-
4
-
-
3
3
-
-
-
-
9
-
3
-
-
6
3
-
-
-
12
-
-
-
-
3
-
1
-
-
-
21
12
6
-
-
-
9
-
-
-
3
-
-
-
-
9
-
3
-
-
6
3
-
-
-
-
3
3
-
6
6
731666
Chen
-
Prokaryotic expression and act ...
Mycobacterium tuberculosis
Chin. J. Microbiol. Immunol.
32
589-594
2012
-
-
1
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1
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2
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1
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2
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1
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1
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1
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1
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2
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1
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2
-
-
-
-
2
-
2
-
1
-
2
-
1
-
-
1
1
-
-
-
732651
Waduwara-Jayabahu
Recycling of methylthioadenosi ...
Arabidopsis thaliana
Plant Physiol.
158
1728-1744
2012
-
-
-
-
-
-
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1
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3
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3
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1
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1
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3
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1
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-
1
1
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-
-
709718
Siu
Mechanism of substrate specifi ...
Arabidopsis thaliana, Escherichia coli
J. Struct. Biol.
173
86-98
2011
-
-
2
1
1
-
-
2
-
-
-
4
-
2
-
-
2
-
-
-
1
-
7
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
1
1
-
-
-
-
2
-
-
-
4
-
-
-
2
-
-
1
-
7
2
-
-
-
-
2
-
-
-
-
2
2
-
-
-
716846
Bretes
5'-methylthioadenosine nucleos ...
Lupinus luteus
Protein Pept. Lett.
18
817-824
2011
-
-
-
-
4
-
-
-
-
-
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3
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1
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4
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1
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-
698517
Cornell
Assessment of methylthioadenos ...
Borreliella burgdorferi
J. Antimicrob. Chemother.
63
1163-1172
2009
-
-
1
-
-
-
5
2
2
-
-
-
-
5
-
-
1
-
-
-
2
-
1
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-
-
-
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Sekowska
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1
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1
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Cacciapuoti
Studies on phosphate-activated ...
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Sugimoto
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Baxter
In vitro synthesis of spermidi ...
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