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Literature summary for 3.2.2.19 extracted from
- Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase (1993), J. Biol. Chem., 268, 17837-17843.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Meleagris gallopavo |  |
| dithiothreitol | - |
Mus musculus | |
| dithiothreitol | activity is increased about 10fold by 5 mM dithiothreitol | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mus musculus |
| wild-type and mutant human hydrolases are expressed in Escherichia coli | Homo sapiens |
| wild-type and mutant rat hydrolases are expressed in Escherichia coli | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0262 | - |
ADP-ribosylarginine | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Meleagris gallopavo | |
| Mg2+ | - |
Cavia porcellus | |
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
- |
Meleagris gallopavo |
| 39000 | - |
- |
Mus musculus |
| 39000 | - |
- |
Rattus norvegicus |
| 39000 | - |
- |
Bos taurus |
| 39000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose-arginine + H2O | Meleagris gallopavo | - |
ADP-ribose + arginine | - |
? | |
| ADP-ribose-arginine + H2O | Rhodospirillum rubrum | the existence of a ADP-ribosylation cycle was established in the bacterium Rhodospirillium rubrum where it regulates dinitrogenase reductase, a key enzyme in nitrogen fixation | ADP-ribose + arginine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Meleagris gallopavo | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Rhodospirillum rubrum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| erythrocyte | - |
Meleagris gallopavo | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose-arginine + H2O | - |
Meleagris gallopavo | ADP-ribose + arginine | - |
? | |
| ADP-ribose-arginine + H2O | the existence of a ADP-ribosylation cycle was established in the bacterium Rhodospirillium rubrum where it regulates dinitrogenase reductase, a key enzyme in nitrogen fixation | Rhodospirillum rubrum | ADP-ribose + arginine | - |
? | |
| ADP-ribose-L-arginine + H2O | - |
Meleagris gallopavo | ADP-ribose + L-arginine | - |
? | |
| ADP-ribose-L-arginine + H2O | - |
Homo sapiens | ADP-ribose + L-arginine | - |
? | |
| ADP-ribose-L-arginine + H2O | - |
Rattus norvegicus | ADP-ribose + L-arginine | - |
? | |
| ADP-ribosylarginine + H2O | - |
Homo sapiens | ADP-ribose + L-arginine | - |
? | |
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