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Literature summary for 3.2.2.5 extracted from
- NAD glycohydrolases from rat liver nuclei (1986), Methods Enzymol., 66, 151-154.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alpha-NAD+ | 5 mM, 70% inhibition | Rattus norvegicus |  |
| deamino-NAD+ | 5 mM, almost complete inhibition | Rattus norvegicus | |
| NADP+ | 5 mM, almost complete inhibition | Rattus norvegicus | |
| nicotinamide | 50 mM, 33% inhibition | Rattus norvegicus | |
| NMN | 5 mM, 70% inhibition | Rattus norvegicus | |
| thioNAD+ | 5 mM, almost complete inhibition | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
NAD+ | chromatin | Rattus norvegicus | |
| 0.06 | - |
NAD+ | nuclear envelope | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| nucleus | chromatin and nuclear envelope | Rattus norvegicus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + H2O | Rattus norvegicus | - |
ADPribose + nicotinamide | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| dithiothreitol | 1 mM, slight inactivation | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-acetylpyridine adenine dinucleotide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| NAD+ + H2O | - |
Rattus norvegicus | ADPribose + nicotinamide | - |
? | |
| NADP+ + H2O | - |
Rattus norvegicus | phospho-ADPribose + nicotinamide | - |
? | |
| NMN + H2O | - |
Rattus norvegicus | phosphoribose + nicotinamide | - |
? | |
| thioNAD+ + H2O | - |
Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
nuclear envelope | Rattus norvegicus |
| 6.5 | 7 | chromatin | Rattus norvegicus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
5 min, 60°C, retains of 55% of activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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