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Literature summary for 3.2.2.5 extracted from
- NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci (2002), Mol. Microbiol., 44, 257-269.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | derival of isogenic mutant strains deficient in expression of streptolysin O, the enzyme or both, more rapid internalization, as compared to the wild-type strain, into human keratinocytes, and reduced cytotoxicity and apoptosis occur, highly reduced enzyme content | Streptococcus sp. |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secretion | Streptococcus sp. | - |
- |
| additional information | enzyme is incorporated into human host keratinocyte cytoplasm and membranes by aid of streptolysin O | Streptococcus sp. | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
x * 55000, SDS-PAGE | Streptococcus sp. |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + H2O | Streptococcus sp. | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | ADP-ribose + nicotinamide | - |
? |  |
| NAD+ + H2O | Streptococcus sp. 3 | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | ADP-ribose + nicotinamide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus sp. | - |
group A, e.g. virulent M-type 3 strain | - |
| Streptococcus sp. 3 | - |
group A, e.g. virulent M-type 3 strain | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Streptococcus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + H2O | - |
Streptococcus sp. | ADP-ribose + nicotinamide | - |
? | |
| NAD+ + H2O | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | Streptococcus sp. | ADP-ribose + nicotinamide | - |
? | |
| NAD+ + H2O | - |
Streptococcus sp. 3 | ADP-ribose + nicotinamide | - |
? | |
| NAD+ + H2O | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | Streptococcus sp. 3 | ADP-ribose + nicotinamide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 55000, SDS-PAGE | Streptococcus sp. |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAD+-glycohydrolase | - |
Streptococcus sp. |
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Release 2023.1 (January 2023)
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