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Literature summary for 3.2.2.5 extracted from

  • Michos, A.; Gryllos, I.; Hakansson, A.; Srivastava, A.; Kokkotou, E.; Wessels, M.R.
    Enhancement of streptolysin O activity and intrinsic cytotoxic effects of the group A streptococcal toxin, NAD-glycohydrolase (2006), J. Biol. Chem., 281, 8216-8223.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pyogenes the capacity of NADase to enhance streptolysin O-mediated cytotoxicity is not due to a direct effect on pore formation but rather due to depletion of cellular NAD+ and ATP ?
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Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
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Source Tissue

Source Tissue Comment Organism Textmining
additional information streptolysin O (a cholesterol-dependent cytolysin) produced by Streptococcus pyogenes mediates the translocation of Streptococcus pyogenes NAD glycohydrolase into human epithelial cells Streptococcus pyogenes
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the capacity of NADase to enhance streptolysin O-mediated cytotoxicity is not due to a direct effect on pore formation but rather due to depletion of cellular NAD+ and ATP Streptococcus pyogenes ?
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?