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Literature summary for 3.2.2.5 extracted from

  • Riddle, D.J.; Bessen, D.E.; Caparon, M.G.
    Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism (2010), J. Bacteriol., 192, 3735-3746.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
genotyping, SPN has a different pattern of polymorphisms than Streptococcus pyogenes housekeeping genes. The ratio of nonsynonymous to synonymous nucleotide polymorphisms reveals different patterns of evolution for NADase-active and NADase-inactive strains. SPN amino acid sequence remains preserved despite loss of NADase activity, overview Streptococcus pyogenes

Inhibitors

Inhibitors Comment Organism Structure
protein IFS an endogenous inhibitor, encoded by gene ifs Streptococcus pyogenes

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
 diverse strains, gene spn
-

Synonyms

Synonyms Comment Organism
NAD+ glycohydrolase
-
 Streptococcus pyogenes
SPN
-
 Streptococcus pyogenes

General Information

General Information Comment Organism
additional information models of molecular evolution shows that SPN is evolving under positive selection and diverging into NAD+ glycohydrolase-active and -inactive subtypes Streptococcus pyogenes
physiological function SPN is a virulence factor that is implicated in contributing to the pathogenesis of severe infections, e.g. of the throat, leading to pharyngitis, or the skin, leading to impetigo. NADase activity does not correlate with invasive disease, but is associated with tissue tropism. The ability to cause infection at both the pharynx and the skin is correlated with NADase-active SPN, while the preference for causing infection at either the throat or the skin is associated with NADase-inactive SPN Streptococcus pyogenes