Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.5 extracted from

  • Kuhn, I.; Kellenberger, E.; Said-Hassane, F.; Villa, P.; Rognan, D.; Lobstein, A.; Haiech, J.; Hibert, M.; Schuber, F.; Muller-Steffner, H.
    Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme (2010), Bioorg. Med. Chem., 18, 7900-7910.
    View publication on PubMed
Search for more literature for 3.2.2.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Schistosoma mansoni

Inhibitors

Inhibitors Comment Organism Structure
cyanidin
-
 Schistosoma mansoni
delphinidin
-
 Schistosoma mansoni
diosmetinidin
-
 Schistosoma mansoni
fisetinidin
-
 Schistosoma mansoni
kuromanin
-
 Schistosoma mansoni
luteolin
-
 Schistosoma mansoni
luteolinidin
-
 Schistosoma mansoni
malvidin
-
 Schistosoma mansoni
additional information not inhibited by rac-catechin, piceatannol, trans-resveratrol, praziquantel, cucurmin, chloroquine, mefloquine, Cibacron Blue 3GA, PJ-34, and 1,8-naphthalimide Schistosoma mansoni
myricetin
-
 Schistosoma mansoni
pelargonidin
-
 Schistosoma mansoni
peonidin
-
 Schistosoma mansoni
petunidin
-
 Schistosoma mansoni
quercetagetin
-
 Schistosoma mansoni
quercetagetinidin
-
 Schistosoma mansoni
quercetin
-
 Schistosoma mansoni
rac-taxifolin
-
 Schistosoma mansoni
robinetin
-
 Schistosoma mansoni

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Blue Sepharose column chromatography, gel filtration Schistosoma mansoni

Source Tissue

Source Tissue Comment Organism Textmining
integument
-
 Schistosoma mansoni
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,N6-etheno NAD+ + H2O
-
 Schistosoma mansoni epsilon-ADP-ribose + nicotinamide + H+
-
 ?

Synonyms

Synonyms Comment Organism
NACE
-
 Schistosoma mansoni
NAD+ catabolizing enzyme
-
 Schistosoma mansoni
NAD+glycohydrolase
-
 Schistosoma mansoni

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0013
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni quercetagetin
0.0023
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni cyanidin
0.0039
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni quercetin
0.0044
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni pelargonidin
0.0056
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni peonidin
0.0058
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni robinetin
0.0059
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni luteolinidin
0.006
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni delphinidin
0.0061
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni quercetagetinidin
0.0064
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni fisetinidin
0.008
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni malvidin
0.0082
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni kuromanin
0.0084
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni luteolin
0.0099
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni diosmetinidin
0.0195
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni rac-taxifolin
0.022
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni myricetin
0.0378
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni petunidin