Literature summary for 3.2.2.5 extracted from

Sharma, O.; OSeaghdha, M.; Velarde, J.J.; Wessels, M.R.
NAD+-glycohydrolase promotes intracellular survival of group A Streptococcus (2016), PLoS Pathog., 12, e1005468 .

Search for more literature for 3.2.2.5

Application

Application	Comment	Organism
analysis	NADase fused to an amino-terminal fragment of anthrax toxin lethal factor is translocated across a synthetic lipid bilayer in vitro in the presence of anthrax toxin protective antigen in a pH-dependent manner. Exposure of human oropharyngeal keratinocytes to the fused NADase in the presence of protective antigen results in cytosolic delivery of NADase activity, inhibition of protein synthesis, and cell death	Streptococcus pyogenes serotype M3

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pyogenes serotype M3	A0A0H2UTN5	-	-

Purification (Commentary)

Purification (Comment)	Organism
method for purification of enzymatically active NADase fused to an amino-terminal fragment of anthrax toxin lethal factor	Streptococcus pyogenes serotype M3

General Information

General Information	Comment	Organism
physiological function	anthrax toxin-mediated delivery of NADase in an amount comparable to that observed during in vitro infection with live group A Streptococcus rescues the defective intracellular survival of NADase-deficient group A Streptococcus and increases the survival of streptolysin-deficient group A Streptococcus	Streptococcus pyogenes serotype M3

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Release 2023.1 (January 2023)