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Literature summary for 3.2.2.6 extracted from

  • Kwong, A.; Chen, Z.; Zhang, H.; Leung, F.; Lam, C.; Ting, K.; Zhang, L.; Hao, Q.; Zhang, L.; Lee, H.
    Catalysis-based inhibitors of the calcium signaling function of CD38 (2012), Biochemistry, 51, 555-564.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with inhibitors, hanging drop vapor diffusion method, mixing of 10 mg/ml protein in 20 mM HEPES with 5 mm ligands, with reservoir solution containing 0.1 M sodium acetate, pH 4.0, 0.2 M ammonium acetate, 3% 2-propanol, and 15% PEG 10000, X-ray diffraction structure determination and analysis, molecular replacement Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Homo sapiens
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Mus musculus
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Rattus norvegicus
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Homo sapiens
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Mus musculus
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Rattus norvegicus
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Homo sapiens
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Mus musculus
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Homo sapiens
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Mus musculus
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium inhibition of the NADase activity Rattus norvegicus
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide inhibition of the NADase activity Homo sapiens
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide inhibition of the NADase activity Mus musculus
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide inhibition of the NADase activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclic ADP-ribose + H2O Rattus norvegicus
-
ADP-D-ribose
-
?
cyclic ADP-ribose + H2O Homo sapiens
-
ADP-D-ribose
-
?
cyclic ADP-ribose + H2O Mus musculus
-
ADP-D-ribose
-
?
NAD+ Rattus norvegicus
-
cyclic ADP-ribose + nicotinamide
-
?
NAD+ Homo sapiens
-
cyclic ADP-ribose + nicotinamide
-
?
NAD+ Mus musculus
-
cyclic ADP-ribose + nicotinamide
-
?
NAD+ + H2O Rattus norvegicus overall reaction ADP-D-ribose + nicotinamide
-
?
NAD+ + H2O Homo sapiens overall reaction ADP-D-ribose + nicotinamide
-
?
NAD+ + H2O Mus musculus overall reaction ADP-D-ribose + nicotinamide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28907
-
-
Mus musculus P56528
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
HL-60 cell
-
Homo sapiens
-
mesenteric artery
-
Rattus norvegicus
-
ventricular zone
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic ADP-ribose + H2O
-
Rattus norvegicus ADP-D-ribose
-
?
cyclic ADP-ribose + H2O
-
Homo sapiens ADP-D-ribose
-
?
cyclic ADP-ribose + H2O
-
Mus musculus ADP-D-ribose
-
?
NAD+
-
Rattus norvegicus cyclic ADP-ribose + nicotinamide
-
?
NAD+
-
Homo sapiens cyclic ADP-ribose + nicotinamide
-
?
NAD+
-
Mus musculus cyclic ADP-ribose + nicotinamide
-
?
NAD+ + H2O overall reaction Rattus norvegicus ADP-D-ribose + nicotinamide
-
?
NAD+ + H2O overall reaction Homo sapiens ADP-D-ribose + nicotinamide
-
?
NAD+ + H2O overall reaction Mus musculus ADP-D-ribose + nicotinamide
-
?

Synonyms

Synonyms Comment Organism
CD38
-
Rattus norvegicus
CD38
-
Homo sapiens
CD38
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus
37
-
assay at Homo sapiens
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus
7.4
-
assay at Homo sapiens
7.4
-
assay at Mus musculus

General Information

General Information Comment Organism
malfunction ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior Rattus norvegicus
malfunction ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior Homo sapiens
malfunction ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior Mus musculus
additional information structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226 Rattus norvegicus
additional information structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226 Homo sapiens
additional information structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226 Mus musculus
physiological function the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules Rattus norvegicus
physiological function the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules Homo sapiens
physiological function the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules Mus musculus