Crystallization (Comment) | Organism |
---|---|
enzyme in complex with inhibitors, hanging drop vapor diffusion method, mixing of 10 mg/ml protein in 20 mM HEPES with 5 mm ligands, with reservoir solution containing 0.1 M sodium acetate, pH 4.0, 0.2 M ammonium acetate, 3% 2-propanol, and 15% PEG 10000, X-ray diffraction structure determination and analysis, molecular replacement | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Homo sapiens | |
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Mus musculus | |
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Rattus norvegicus | |
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Homo sapiens | |
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Mus musculus | |
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Rattus norvegicus | |
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Homo sapiens | |
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Mus musculus | |
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Homo sapiens | |
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Mus musculus | |
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium | inhibition of the NADase activity | Rattus norvegicus | |
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide | inhibition of the NADase activity | Homo sapiens | |
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide | inhibition of the NADase activity | Mus musculus | |
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide | inhibition of the NADase activity | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclic ADP-ribose + H2O | Rattus norvegicus | - |
ADP-D-ribose | - |
? | |
cyclic ADP-ribose + H2O | Homo sapiens | - |
ADP-D-ribose | - |
? | |
cyclic ADP-ribose + H2O | Mus musculus | - |
ADP-D-ribose | - |
? | |
NAD+ | Rattus norvegicus | - |
cyclic ADP-ribose + nicotinamide | - |
? | |
NAD+ | Homo sapiens | - |
cyclic ADP-ribose + nicotinamide | - |
? | |
NAD+ | Mus musculus | - |
cyclic ADP-ribose + nicotinamide | - |
? | |
NAD+ + H2O | Rattus norvegicus | overall reaction | ADP-D-ribose + nicotinamide | - |
? | |
NAD+ + H2O | Homo sapiens | overall reaction | ADP-D-ribose + nicotinamide | - |
? | |
NAD+ + H2O | Mus musculus | overall reaction | ADP-D-ribose + nicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28907 | - |
- |
Mus musculus | P56528 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
HL-60 cell | - |
Homo sapiens | - |
mesenteric artery | - |
Rattus norvegicus | - |
ventricular zone | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclic ADP-ribose + H2O | - |
Rattus norvegicus | ADP-D-ribose | - |
? | |
cyclic ADP-ribose + H2O | - |
Homo sapiens | ADP-D-ribose | - |
? | |
cyclic ADP-ribose + H2O | - |
Mus musculus | ADP-D-ribose | - |
? | |
NAD+ | - |
Rattus norvegicus | cyclic ADP-ribose + nicotinamide | - |
? | |
NAD+ | - |
Homo sapiens | cyclic ADP-ribose + nicotinamide | - |
? | |
NAD+ | - |
Mus musculus | cyclic ADP-ribose + nicotinamide | - |
? | |
NAD+ + H2O | overall reaction | Rattus norvegicus | ADP-D-ribose + nicotinamide | - |
? | |
NAD+ + H2O | overall reaction | Homo sapiens | ADP-D-ribose + nicotinamide | - |
? | |
NAD+ + H2O | overall reaction | Mus musculus | ADP-D-ribose + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD38 | - |
Rattus norvegicus |
CD38 | - |
Homo sapiens |
CD38 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior | Rattus norvegicus |
malfunction | ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior | Homo sapiens |
malfunction | ablation of the CD38 gene in mice causes multiple physiological defects, including impaired oxytocin release, that result in altered social behavior | Mus musculus |
additional information | structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226 | Rattus norvegicus |
additional information | structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226 | Homo sapiens |
additional information | structure-function relationship anaysis, overview. Covalent intermediates are formed with the catalytic residue, Glu226 | Mus musculus |
physiological function | the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules | Rattus norvegicus |
physiological function | the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules | Homo sapiens |
physiological function | the enzyme is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate, both are universal Ca2+ messenger molecules | Mus musculus |