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Literature summary for 3.3.2.9 extracted from

  • Lu, A.Y.H.; Thomas, P.E.; Ryan, D.; Jerina, D.M.; Levin, W.
    Purification of human liver microsomal epoxide hydrase. Differences in the properties of the human and rat enzymes (1979), J. Biol. Chem., 254, 5878-5881.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Metyrapone
-
Rattus norvegicus
Metyrapone great stimulation of hydration of styrene 7,8-oxide and octene 1,2-oxide, slight stimulation of hydration of benzopyrane 4,5-oxide Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-Bromo-4'-nitroacetophenone
-
Homo sapiens
2-Bromo-4'-nitroacetophenone
-
Rattus norvegicus
Cyclohexene oxide
-
Homo sapiens
Cyclohexene oxide
-
Rattus norvegicus
Metyrapone strong inhibition of hydration of benzopyrene 11,12-oxide and dibenzoanthracene 5,6-oxide Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
49000
-
x * 49000, SDS-PAGE Homo sapiens
49000
-
x * 49000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.618
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoanthracene 5,6-oxide + H2O
-
Homo sapiens ?
-
?
benzoanthracene 5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
benzopyrene 11,12-oxide + H2O
-
Rattus norvegicus ?
-
?
benzopyrene 4,5-oxide + H2O
-
Homo sapiens (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Rattus norvegicus (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 7,8-oxide + H2O
-
Homo sapiens ?
-
?
benzopyrene 7,8-oxide + H2O
-
Rattus norvegicus ?
-
?
dibenzanthracene 5,6-oxide + H2O
-
Homo sapiens ?
-
?
dibenzanthracene 5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
octene 1,2-oxide + H2O
-
Homo sapiens ?
-
?
octene 1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
phenanthrene-9,10-oxide + H2O
-
Homo sapiens ?
-
?
phenanthrene-9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
styrene 7,8-oxide + H2O
-
Homo sapiens styrene glycol
-
?
styrene 7,8-oxide + H2O
-
Rattus norvegicus styrene glycol
-
?

Subunits

Subunits Comment Organism
? x * 49000, SDS-PAGE Homo sapiens
? x * 49000, SDS-PAGE Rattus norvegicus