Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | complete inactivation, reversible by Zn2+, Co2+, Ni2+, or Cu2+ | Vibrio proteolyticus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Pseudomonas aeruginosa | - |
- |
extracellular | - |
Vibrio proteolyticus | - |
- |
intracellular | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 5622 | - |
intracellular | - |
Escherichia coli | 5622 | - |
intracellular | - |
Pseudomonas aeruginosa | 5622 | - |
intracellular | - |
Vibrio proteolyticus | 5622 | - |
plasma membrane | the enzyme is asscoiated to the internal membrane surface | Lactococcus sp. | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | metallopeptidase, the kind of bound metal ion determines the substrate specificity | Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | metallopeptidase, the kind of bound metal ion determines the substrate specificity | Escherichia coli | |
additional information | metallopeptidase, the kind of bound metal ion determines the substrate specificity | Vibrio proteolyticus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
extracellular enzymes show a low MW of 20-30 kDa | Pseudomonas aeruginosa |
additional information | - |
extracellular enzymes show a low MW of 20-30 kDa | Vibrio proteolyticus |
18000 | - |
12 * 18000 | Brevibacterium linens |
47000 | - |
x * 47000 + x * 50000 | Mycoplasma salivarium |
50000 | - |
8 * 50000, about | Pseudomonas putida |
50000 | - |
x * 47000 + x * 50000 | Mycoplasma salivarium |
55000 | - |
6 * 55000 | Escherichia coli |
400000 | - |
- |
Pseudomonas putida |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Salmonella enterica subsp. enterica serovar Typhimurium | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Escherichia coli | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Pseudomonas aeruginosa | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Pseudomonas putida | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Brevibacterium linens | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Vibrio proteolyticus | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Mycoplasma salivarium | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Lactococcus sp. | the enzyme is involved in transport and degradation of extracellular peptides, and are important in uptake of nutrients, regulation, overview | ? | - |
? | |
additional information | Brevibacterium linens SR3 | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brevibacterium linens | - |
- |
- |
Brevibacterium linens SR3 | - |
- |
- |
Escherichia coli | - |
- |
- |
Lactococcus sp. | - |
- |
- |
Mycoplasma salivarium | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas putida | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Vibrio proteolyticus | - |
formerly Aeromonas proteolytica | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Escherichia coli | ? | - |
? | |
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Pseudomonas aeruginosa | ? | - |
? | |
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Pseudomonas putida | ? | - |
? | |
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Brevibacterium linens | ? | - |
? | |
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Vibrio proteolyticus | ? | - |
? | |
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Mycoplasma salivarium | ? | - |
? | |
additional information | the enzyme is involved in transport and degradation of extracellular peptides, and are important in uptake of nutrients, regulation, overview | Lactococcus sp. | ? | - |
? | |
additional information | the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
additional information | the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position | Escherichia coli | ? | - |
? | |
additional information | the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position | Pseudomonas aeruginosa | ? | - |
? | |
additional information | the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position | Vibrio proteolyticus | ? | - |
? | |
additional information | aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview | Brevibacterium linens SR3 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 47000 + x * 50000 | Mycoplasma salivarium |
dodecamer | 12 * 18000 | Brevibacterium linens |
hexamer | 6 * 55000 | Escherichia coli |
octamer | 8 * 50000, about | Pseudomonas putida |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase A | - |
Escherichia coli |
aminopeptidase A | - |
Lactococcus sp. |
bacterial leucine aminopeptidase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
bacterial leucine aminopeptidase | - |
Escherichia coli |
bacterial leucine aminopeptidase | - |
Pseudomonas aeruginosa |
bacterial leucine aminopeptidase | - |
Pseudomonas putida |
bacterial leucine aminopeptidase | - |
Brevibacterium linens |
bacterial leucine aminopeptidase | - |
Vibrio proteolyticus |
PepA | - |
Escherichia coli |