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Literature summary for 3.4.11.10 extracted from

  • Wilkes, S.H.; Prescott, J.M.
    Stereospecificity of amino acid hydroxamate inhibition of aminopeptidases (1983), J. Biol. Chem., 258, 13517-13521.
    View publication on PubMed

General Stability

General Stability Organism
generally extremely stable Vibrio proteolyticus

Inhibitors

Inhibitors Comment Organism Structure
Amino acid hydroxamates
-
Vibrio proteolyticus
D-Leu-hydroxamate Ki: 2 nM, L-isomer bound 150 times less tightly Vibrio proteolyticus
D-Val-hydroxamate Ki: 5 nM Vibrio proteolyticus
DL-Ala-hydroxamate Ki: 0.0055 mM Vibrio proteolyticus
DL-Phe-hydroxamate Ki: 0.0008 mM Vibrio proteolyticus
DL-Thr-hydroxamate Ki: 0.002 mM Vibrio proteolyticus
DL-Val-hydroxamate Ki: 10 nM Vibrio proteolyticus
L-Ala-hydroxamate Ki: 0.02 mM Vibrio proteolyticus
L-Phe-hydroxamate Ki: 0.0088 mM Vibrio proteolyticus
L-Thr-hydroxamate Ki: 0.066 mM Vibrio proteolyticus
L-Val-hydroxamate Ki: 0.0022 mM Vibrio proteolyticus
additional information inhibited to a greater extend by D- than by L-hydroxamates of amino acids and aliphatic acids, pH-dependent Vibrio proteolyticus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Peptides + H2O Vibrio proteolyticus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Vibrio proteolyticus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Peptides + H2O
-
Vibrio proteolyticus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Vibrio proteolyticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
D-Leu-hydroxamate L-isomer bound 150 times less tightly Vibrio proteolyticus
0.000005
-
D-Val-hydroxamate
-
Vibrio proteolyticus
0.00001
-
DL-Val-hydroxamate
-
Vibrio proteolyticus
0.0008
-
DL-Phe-hydroxamate
-
Vibrio proteolyticus
0.002
-
DL-Thr-hydroxamate
-
Vibrio proteolyticus
0.0022
-
L-Thr-hydroxamate
-
Vibrio proteolyticus
0.0055
-
DL-Ala-hydroxamate
-
Vibrio proteolyticus
0.0088
-
L-Phe-hydroxamate
-
Vibrio proteolyticus
0.02
-
L-Ala-hydroxamate
-
Vibrio proteolyticus
860
-
L-Val-hydroxamate
-
Vibrio proteolyticus