Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | 50% inhibition at 0.6 mM | Sus scrofa | |
amastatin | 50% inhibition at 0.002 mM | Sus scrofa | |
bestatin | 50% inhibition at 0.006 mM | Sus scrofa | |
captopril | 50% inhibition at 0.3 mM | Sus scrofa | |
Co2+ | 65-90% inhibition at 1 mM | Sus scrofa | |
Cu2+ | 65-90% inhibition at 1 mM | Sus scrofa | |
dithiothreitol | 50% inhibition at 0.1 mM | Sus scrofa | |
additional information | many group-specific inhibitors for cysteine proteases have no effect | Sus scrofa | |
Ni2+ | 25% inhibition at 1 mM | Sus scrofa | |
phosphate | - |
Sus scrofa | |
Zn2+ | 65-90% inhibition at 1 mM, reactivated at 10 mM EDTA | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.488 | - |
Leu-Trp | - |
Sus scrofa | |
0.568 | - |
Glu-Trp | - |
Sus scrofa | |
0.625 | - |
Ala-Trp | - |
Sus scrofa | |
1.7 | - |
Pro-Trp | - |
Sus scrofa | |
1.757 | - |
Gly-Trp | - |
Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microvillus | - |
Sus scrofa | 5902 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | 1.2 mol zinc per mol enzyme, probably involved in catalysis | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Peptides + H2O | Sus scrofa | involved in intestinal digestion of small, pre-digested peptide fragments | ? | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | 31% carbohydrates | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Sus scrofa | - |
kidney | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity highly buffer-dependent, optimal in 100 mM Tris-HCl | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Trp + H2O | - |
Sus scrofa | Ala + Trp | - |
ir | |
Arg-Trp + H2O | - |
Sus scrofa | Arg + Trp | - |
ir | |
Asp-Phe + H2O | - |
Sus scrofa | Asp + Phe | - |
ir | |
Glu-Trp + H2O | - |
Sus scrofa | Glu + Trp | - |
ir | |
Glu-Tyr + H2O | - |
Sus scrofa | Glu + Tyr | - |
ir | |
Gly-Trp + H2O | - |
Sus scrofa | Gly + Trp | - |
ir | |
Gly-Tyr + H2O | - |
Sus scrofa | Gly + Tyr | - |
ir | |
Ile-Phe + H2O | - |
Sus scrofa | Ile + Phe | - |
ir | |
Ile-Trp + H2O | - |
Sus scrofa | Ile + Trp | - |
ir | |
Leu-Phe + H2O | - |
Sus scrofa | Leu + Phe | - |
ir | |
Leu-Trp + H2O | - |
Sus scrofa | Leu + Trp | - |
ir | |
Leu-Tyr + H2O | - |
Sus scrofa | Leu + Tyr | - |
ir | |
Peptides + H2O | involved in intestinal digestion of small, pre-digested peptide fragments | Sus scrofa | ? | - |
ir | |
Phe-Phe + H2O | - |
Sus scrofa | Phe + Phe | - |
ir | |
Phe-Trp + H2O | - |
Sus scrofa | Phe + Trp | - |
ir | |
Phe-Tyr + H2O | - |
Sus scrofa | Phe + Tyr | - |
ir | |
Pro-Trp + H2O | - |
Sus scrofa | Pro + Trp | - |
ir | |
Trp-Phe + H2O | - |
Sus scrofa | Trp + Phe | - |
ir | |
Trp-Trp + H2O | - |
Sus scrofa | Trp + Trp | - |
ir | |
Tyr-Leu + H2O | - |
Sus scrofa | Tyr + Leu | - |
ir | |
Tyr-Phe + H2O | - |
Sus scrofa | Tyr + Phe | - |
ir | |
Val-Trp + H2O | - |
Sus scrofa | Val + Trp | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase W | - |
Sus scrofa |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
29.6 | - |
Pro-Trp | - |
Sus scrofa | |
38.5 | - |
Ala-Trp | - |
Sus scrofa | |
92.6 | - |
Leu-Trp | - |
Sus scrofa | |
113 | - |
Glu-Trp | - |
Sus scrofa | |
127 | - |
Gly-Trp | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Sus scrofa |