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Literature summary for 3.4.11.2 extracted from

  • Lalu, K.; Lampelo, S.; Vanha-Perttula, T.
    Characterization of three aminopeptidases purified from maternal serum (1986), Biochim. Biophys. Acta, 873, 190-197.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
alanine
-
 Homo sapiens
arginine
-
 Homo sapiens
EDTA
-
 Homo sapiens
epsilon-amino-n-caproic acid 70% inhibition at 100 mM Homo sapiens
glutamine
-
 Homo sapiens
leucine
-
 Homo sapiens
methionine
-
 Homo sapiens
puromycin 93% inhibition at 1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.054
-
 Lys-2-naphthylamide
-
 Homo sapiens
0.068
-
 L-Met-2-naphthylamide
-
 Homo sapiens
0.075
-
 L-Arg-2-naphthylamide
-
 Homo sapiens
0.095
-
 Leu-2-naphthylamide
-
 Homo sapiens
0.117
-
 L-Gln-2-naphthylamide
-
 Homo sapiens
0.256
-
 Ala-2-naphthylamide
-
 Homo sapiens
0.327
-
 Phe-2-naphthylamide
-
 Homo sapiens
0.329
-
 Tyr-2-naphthylamide
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ increase of activity Homo sapiens
Ni2+ reactivation after inhibition by EDTA Homo sapiens
Zn2+ reactivation after inhibition by EDTA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aminoacyl peptide Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-2-naphthylamide + H2O
-
 Homo sapiens Ala + 2-naphthylamine
-
 ?
aminoacyl peptide
-
 Homo sapiens ?
-
 ?
aminoacyl-2-naphthylamide + H2O
-
 Homo sapiens amino acid + 2-naphthylamine
-
 ?
L-Arg-2-naphthylamide + H2O
-
 Homo sapiens L-Arg + 2-naphthylamine
-
 ?
L-Gln-2-naphthylamide + H2O
-
 Homo sapiens L-Gln + 2-naphthylamine
-
 ?
L-Lys-2-naphthylamide + H2O
-
 Homo sapiens L-Lys + 2-naphthylamine
-
 ?
L-Met-2-naphthylamide + H2O
-
 Homo sapiens L-Met + 2-naphthylamine
-
 ?
L-Phe-2-naphthylamide + H2O
-
 Homo sapiens L-Phe + 2-naphthylamine
-
 ?
L-Tyr-2-naphthylamide + H2O
-
 Homo sapiens L-Tyr + 2-naphthylamine
-
 ?
Leu-2-naphthylamide + H2O
-
 Homo sapiens Leu + 2-naphthylamine
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
 60% activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.75 7 substrate Ala-2-naphtylamide Homo sapiens