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Literature summary for 3.4.11.3 extracted from

  • Demaegdt, H.; Lenaerts, P.J.; Swales, J.; De Backer, J.P.; Laeremans, H.; Le, M.T.; Kersemans, K.; Vogel, L.K.; Michotte, Y.; Vanderheyden, P.; Vauquelin, G.
    Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme (2006), Eur. J. Pharmacol., 546, 19-27.
    View publication on PubMed
Search for more literature for 3.4.11.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cell Cricetulus griseus
expression in HEK-293 cell Homo sapiens
expression in HEK-293 cell Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
angiotensin 4-8
-
 Bos taurus
angiotensin 4-8
-
 Cricetulus griseus
angiotensin 4-8
-
 Homo sapiens
angiotensin 4-8
-
 Mus musculus
angiotensin II
-
 Bos taurus
angiotensin II
-
 Cricetulus griseus
angiotensin II
-
 Homo sapiens
angiotensin II
-
 Mus musculus
angiotensin III
-
 Bos taurus
angiotensin III
-
 Cricetulus griseus
angiotensin III
-
 Homo sapiens
angiotensin III
-
 Mus musculus
angiotensin IV
-
 Bos taurus
angiotensin IV
-
 Cricetulus griseus
angiotensin IV
-
 Homo sapiens
angiotensin IV
-
 Mus musculus
divalinal
-
 Bos taurus
divalinal
-
 Cricetulus griseus
divalinal
-
 Homo sapiens
divalinal
-
 Mus musculus
LVV-hemorphin 7
-
 Bos taurus
LVV-hemorphin 7
-
 Cricetulus griseus
LVV-hemorphin 7
-
 Homo sapiens
LVV-hemorphin 7
-
 Mus musculus
additional information inhibitory potency in decreasing order: angiotensin III, angiotensin IV, LVV-hemorphin 7, divalinal/angiotensin IV, angiotensin II, angiotensin 4-8 Bos taurus
additional information inhibitory potency in decreasing order: angiotensin IV, angiotensin III, LVV-hemorphin 7, divalinal/angiotensin IV, angiotensin 4-8, angiotensin III Cricetulus griseus
additional information inhibitory potency in decreasing order: angiotensin IV, angiotensin III, divalinal/angiotensin IV, LVV-hemorphin 7, angiotensin 4-8, angiotensin III Homo sapiens
additional information inhibitory potency in decreasing order: angiotensin IV, angiotensin III, divalinal/angiotensin IV, LVV-hemorphin 7, angiotensin 4-8, angiotensin III Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
 L-Leu-4-nitroanilide pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Cricetulus griseus 16020
-
membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Mus musculus 16020
-
membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Homo sapiens 16020
-
membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Bos taurus 16020
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO-K1 cell
-
 Cricetulus griseus
-
HEK-293 cell
-
 Homo sapiens
-
MDBK cell Madin-Darby bovine kidney cell Bos taurus
-
SK-N-MC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-4-nitroanilide + H2O
-
 Cricetulus griseus L-Leu + 4-nitroaniline
-
 ?
L-Leu-4-nitroanilide + H2O
-
 Mus musculus L-Leu + 4-nitroaniline
-
 ?
L-Leu-4-nitroanilide + H2O
-
 Homo sapiens L-Leu + 4-nitroaniline
-
 ?
L-Leu-4-nitroanilide + H2O
-
 Bos taurus L-Leu + 4-nitroaniline
-
 ?