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Literature summary for 3.4.11.7 extracted from

  • Llorens-Cortes, C.; Kordon, C.
    Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems (2008), J. Neuroendocrinol., 20, 279-289.
    View publication on PubMed
Search for more literature for 3.4.11.7

Application

Application Comment Organism
medicine APA is a new potential therapeutic target for the treatment of certain forms of hypertension Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
amastatin
-
 Rattus norvegicus
bestatin
-
 Rattus norvegicus
EC33
-
 Rattus norvegicus
RB150
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
 monomer Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Rattus norvegicus angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00025
-
 EC33
-
 Rattus norvegicus