Literature summary for 3.4.11.7 extracted from

de Mota, N.; Iturrioz, X.; Claperon, C.; Bodineau, L.; Fassot, C.; Roques, B.P.; Palkovits, M.; Llorens-Cortes, C.
Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei (2008), J. Neurochem., 106, 416-428.

Search for more literature for 3.4.11.7

Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-3-amino-4-mercapto-butylsulfonic acid	specific and selective aminopeptidase A inhibitor	Homo sapiens
(S)-3-amino-4-mercapto-butylsulfonic acid	specific and selective APA inhibitor	Mus musculus
2-amino-4-methylsulfonyl butane thiol	weak inhibitor of aminopeptidase A	Homo sapiens
2-amino-4-methylsulfonyl butane thiol	weak inhibitor of APA	Mus musculus
bestatin	-	Homo sapiens
bestatin	-	Mus musculus
captopril	-	Homo sapiens
captopril	-	Mus musculus
L-glutamate phosphinic acid	-	Homo sapiens
L-glutamate phosphinic acid	-	Mus musculus
methionine thiol	-	Homo sapiens
methionine thiol	-	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	maximal activation at 4 mM Ca2+	Mus musculus
Ca2+	maximal activation at 4 mM Ca2+	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
brain	-	Homo sapiens	-
choroid plexus	-	Homo sapiens	-
hypothalamus	highest activity	Homo sapiens	-
medulla oblongata	dorsomedial part, highest activity	Homo sapiens	-
nucleus accumbens	highest activity	Homo sapiens	-
olfactory bulb	highest activity	Homo sapiens	-
paraventricular nucleus	highest activity	Homo sapiens	-
pineal gland	-	Homo sapiens	-
prefrontal cortex	highest activity	Homo sapiens	-
spinal cord	-	Homo sapiens	-
supraoptic nucleus	highest activity	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensin II + H2O	-	Mus musculus	L-aspartic acid + angiotensin III	-	?
angiotensin II + H2O	-	Homo sapiens	L-aspartic acid + angiotensin III	-	?
L-Glu-2-naphthylamide + H2O	-	Mus musculus	L-Glu + 2-naphthylamine	-	?
L-Glu-2-naphthylamide + H2O	-	Homo sapiens	L-Glu + 2-naphthylamine	-	?

Synonyms

Synonyms	Comment	Organism
aminopeptidase A	-	Mus musculus
aminopeptidase A	-	Homo sapiens
APA	-	Mus musculus
APA	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)