Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.9 extracted from

  • Harbeck, H.T.; Mentlein, R.
    Aminopeptidase P from rat brain. Purification and action on bioactive peptides (1991), Eur. J. Biochem., 198, 451-458.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Rattus norvegicus
4-hydroxymercuribenzoate
-
Rattus norvegicus
amastatin
-
Rattus norvegicus
Aprotinin
-
Rattus norvegicus
bestatin
-
Rattus norvegicus
Ca2+ 1 mM CaCl2, 27% inhibition Rattus norvegicus
Cd2+
-
Rattus norvegicus
Co2+ 1 mM CoCl2, 90% inhibition Rattus norvegicus
EDTA
-
Rattus norvegicus
EGTA
-
Rattus norvegicus
Hg2+
-
Rattus norvegicus
iodoacetate
-
Rattus norvegicus
NEM
-
Rattus norvegicus
Pb2+
-
Rattus norvegicus
puromycin
-
Rattus norvegicus
Zn2+ 1 mM ZnSO4, 96% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
Arg-Pro-Pro
-
Rattus norvegicus
0.28
-
bradykinin
-
Rattus norvegicus
0.6
-
Tyr-Pro-Phe-Pro-Gly-Pro-Ile
-
Rattus norvegicus
0.72
-
Tyr-Pro-Leu-Gly-NH2
-
Rattus norvegicus
1.02
-
Tyr-Pro-Phe-Pro-Gly
-
Rattus norvegicus
1.23
-
Arg-Pro
-
Rattus norvegicus
1.33
-
L-Tyr-L-Pro-L-Phe-NH2
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
143000
-
with 0.14 M NaCl, gel filtration Rattus norvegicus
218000
-
without NaCl, gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
31.7
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
4°C, bicine buffer, pH 7.8, 1 mM dithiothreitol, 1 mM MnCl2, stable for several weeks Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Pro + H2O
-
Rattus norvegicus Ala + Pro
-
?
Arg-Pro + H2O
-
Rattus norvegicus Arg + Pro
-
?
Arg-Pro-Pro + H2O
-
Rattus norvegicus Arg + Pro-Pro
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
-
Rattus norvegicus Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
?
L-Tyr-L-Pro-L-Phe-NH2 + H2O
-
Rattus norvegicus L-Tyr + L-Pro-L-Phe-NH2
-
?
additional information the enzyme liberates all unblocked preferentially basic or hydrophobic ultimate amino acids from dipeptides, tripeptides and oligopeptides with N-terminal Xaa-Pro- sequences, overview Rattus norvegicus ?
-
?
Tyr-Pro-Leu-Gly-NH2 + H2O
-
Rattus norvegicus ?
-
?
Tyr-Pro-Phe-Pro-Gly + H2O
-
Rattus norvegicus ?
-
?
Tyr-Pro-Phe-Pro-Gly-Pro-Ile + H2O
-
Rattus norvegicus ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
pH 7.8, graduall loss of activity Rattus norvegicus
45
-
pH 7.8, rapid denaturation above Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
26
-
Tyr-Pro-Phe-Pro-Gly-Pro-Ile
-
Rattus norvegicus
32
-
Tyr-Pro-Phe-Pro-Gly
-
Rattus norvegicus
38
-
bradykinin
-
Rattus norvegicus
40
-
Tyr-Pro-Leu-Gly-NH2
-
Rattus norvegicus
49
-
Arg-Pro-Pro
-
Rattus norvegicus
58
-
L-Tyr-L-Pro-L-Phe-NH2
-
Rattus norvegicus
73
-
Arg-Pro
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6 8 hydrolysis of Arg-Pro-Pro, Ala-Pro or Tyr-Pro-Leu-Gly-NH2 Rattus norvegicus