Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.1 extracted from

  • McDonald, J.K.; Zeitman, B.B.; Reilly, T.J.; Ellis, S.
    New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones (1969), J. Biol. Chem., 244, 2693-2709.
    View publication on PubMed
Search for more literature for 3.4.14.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Rattus norvegicus
additional information
-
 additional information
-
 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Br- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus
Cl-
-
 Bos taurus
Cl- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus
F- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus
I- absolute requirement for halide ions, the efficacy in decreasing order: Cl-, Br-, I-, F- Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
spleen
-
 Rattus norvegicus
-
spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 Gly-L-Phe-NH2 + 4 H2O polymerization Bos taurus Gly-Phe-Gly-Phe-Gly-Phe-Gly-Phe-NH2 + 3 NH3
-
 ?
5 Gly-Arg-2-naphthylamide + 5 H2O polymerization Bos taurus (Gly-Arg-)5-2-naphthylamide + 4 2-naphthylamine polymers up to (Gly-Arg-)5-2-naphthylamide ?
beta-corticotropin + H2O
-
 Rattus norvegicus Ser-Tyr + Ser-Met + Glu-His + Phe-Arg + Trp-Gly
-
 ?
beta-corticotropin + H2O
-
 Bos taurus Ser-Tyr + Ser-Met + Glu-His + Phe-Arg + Trp-Gly further degradation of corticotropin is prevented by a penultimate prolyl residue ?
Gly-Arg-NH2 + H2O polymerization Bos taurus ?
-
 ?
Gly-Gly-Gly + H2O
-
 Bos taurus Gly-Gly + Gly
-
 ?
Gly-Trp-NH2 + H2O polymerization Bos taurus ?
-
 ?
hexaalanine + H2O
-
 Bos taurus Ala-Ala
-
 ?
Insulin B-chain + H2O bovine, oxidized Rattus norvegicus ?
-
 ?
Insulin B-chain + H2O bovine, oxidized Bos taurus ?
-
 ?
Met-Met-Met + H2O
-
 Bos taurus Met-Met + Met
-
 ?
pentaalanine + H2O
-
 Bos taurus Ala-Ala + Ala-Ala-Ala tri-alanine is resistant to further breakdown ?
Phe-Phe-Phe + H2O
-
 Bos taurus Phe-Phe + Phe
-
 ?
Ser-His-Ala + H2O
-
 Bos taurus Ser-His + Ala
-
 ?
Ser-Met-Glu + H2O
-
 Bos taurus Ser-Met + Glu
-
 ?
tetraglycine + H2O
-
 Bos taurus Gly-Gly
-
 ?
tetraphenylalanine + H2O
-
 Bos taurus Phe-Phe
-
 ?