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Literature summary for 3.4.14.2 extracted from

  • Mentlein, R.; Struckhoff, G.
    Purification of two dipeptidyl aminopeptidases II from rat brain and their action on proline-containing neuropeptides (1989), J. Neurochem., 52, 1284-1293.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bestatin 1 mM, 12% inhibition of DPP II-S, 21% inhibition of DPP II-M; no inhibition Rattus norvegicus
diisopropyl fluorophosphate
-
Rattus norvegicus
additional information no inhibition by bacitracin Rattus norvegicus
N6-benzyloxycarbonyl-Lys-Pro 1 mM, 31% inhibition of DPP II-S, 41% inhibition of DPP II-M Rattus norvegicus
Na+ 400 mM NaCl, 56% inhibition of DPP II-M, 31% inhibition of DPP II-S Rattus norvegicus
p-hydroxymercuribenzoate
-
Rattus norvegicus
phenylmethylsulfonyl fluoride
-
Rattus norvegicus
Tris
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
Gly-Pro-4-nitroanilide enzyme form DPP II-S Rattus norvegicus
0.032
-
Gly-Pro-4-nitroanilide enzyme form DPP II-M Rattus norvegicus
0.068
-
Arg-Pro-4-nitroanilide enzyme form DPP II-M Rattus norvegicus
0.087
-
Lys-Ala-2-naphthylamide enzyme form DPP II-S Rattus norvegicus
0.21
-
Lys-Ala-2-naphthylamide enzyme form DPP II-M Rattus norvegicus
0.502
-
His-Pro-Val enzyme form DPP II-S Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme form DPP II-S Rattus norvegicus 16020
-
soluble enzyme form DPP II-M Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52500
-
2 * 52500, SDS-PAGE Rattus norvegicus
110000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
two enzyme forms: DPP II-M and DPP II-S
-

Purification (Commentary)

Purification (Comment) Organism
enzyme form DPP II-S and DPP II-M Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
hypophysis
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, pH 6.0, 20 mM BisTris-HCl buffer, stable Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Ala-2-naphthylamide + H2O
-
Rattus norvegicus Ala-Ala + 2-naphthylamine
-
?
Arg-Pro-4-nitroanilide + H2O
-
Rattus norvegicus Arg-Pro + 4-nitroaniline
-
?
bradykinin fragment 1-3 + H2O
-
Rattus norvegicus ?
-
?
bradykinin fragment 1-5 + H2O
-
Rattus norvegicus ?
-
?
Gly-Pro-4-nitroanilide + H2O
-
Rattus norvegicus Gly-Pro + 4-nitroaniline
-
?
His-Pro-Val + H2O
-
Rattus norvegicus His-Pro + Val
-
?
Lys-Ala-2-naphthylamide + H2O
-
Rattus norvegicus Lys-Ala + 2-naphthylamine
-
?
additional information no activity with bradykinin Rattus norvegicus ?
-
?
Phe-Pro-2-naphthylamide + H2O
-
Rattus norvegicus Phe-Pro + 2-naphthylamine
-
?

Subunits

Subunits Comment Organism
dimer 2 * 52500, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
DPP II
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
hydrolysis of Gly-Pro-4-nitroanilide or Arg-Pro-4-nitroanilide Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
3
-
4°C, 24 h, loss of activity of DPP II-M Rattus norvegicus
4 8 4°C, 24 h, DPP II-M is stable Rattus norvegicus