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Literature summary for 3.4.15.1 extracted from

  • Hu, J.; Igarashi, A.; Kamata, M.; Nakagawa, H.
    Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (Abeta); retards Abeta aggregation, deposition, fibril formation; and inhibits cytotoxicity (2001), J. Biol. Chem., 276, 47863-47868.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
lisinopril
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta-peptide(1-40) + H2O Homo sapiens cleavage at the Asp7-Ser9 bond. Compared with amyloid beta-peptide(1-40), aggregation and cytotoxic effects of the degradation products amyloid beta-peptide(1-7) and amyloid beta-peptide(8-40) are reduced ot virtually absent. The enzyme inhibits aggregation, deposition, and cytotoxicity of amyloid beta-peptide in vitro may affect susceptibility to Alzheimer‘s disease amyloid beta-peptide(1-7) + amyloid beta-peptide(8-40)
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seminal plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta-peptide(1-40) + H2O cleavage at the Asp7-Ser9 bond Homo sapiens amyloid beta-peptide(1-7) + amyloid beta-peptide(8-40)
-
 ?
amyloid beta-peptide(1-40) + H2O cleavage at the Asp7-Ser9 bond. Compared with amyloid beta-peptide(1-40), aggregation and cytotoxic effects of the degradation products amyloid beta-peptide(1-7) and amyloid beta-peptide(8-40) are reduced ot virtually absent. The enzyme inhibits aggregation, deposition, and cytotoxicity of amyloid beta-peptide in vitro may affect susceptibility to Alzheimer‘s disease Homo sapiens amyloid beta-peptide(1-7) + amyloid beta-peptide(8-40)
-
 ?
p-hydroxyhippuryl-His-Leu + H2O
-
 Homo sapiens ?
-
 ?