Literature summary for 3.4.15.1 extracted from

Oh, H.; Kang, D.G.; Kwon, J.W.; Kwon, T.O.; Lee, S.Y.; Lee, D.B.; Lee, H.S.
Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum (2004), Biol. Pharm. Bull., 27, 2035-2037.

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Inhibitors

Inhibitors	Comment	Organism	Structure
captopril	0.00002 mM	Rattus norvegicus
isorhamnetin-3-beta-glucopyranoside	IC50: 0.4089 mM	Rattus norvegicus
kaempferol-3-alpha-arabinopyranoside	IC50: 0.3928 mM	Rattus norvegicus
additional information	isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum	Rattus norvegicus
quercetin 3-O-alpha-(6''-p-coumaroylglucosyl-beta -1,2-rhamnoside)	IC50: 0.351 mM	Rattus norvegicus
quercetin-3-beta-glucopyranoside	IC50: 0.7088 mM	Rattus norvegicus
quercetin-3-O-alpha-(6''-caffeoylglucosyl-beta-1,2-rhamnoside)	IC50: 0.1589 mM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hippuryl-His-Leu + H2O	-	Rattus norvegicus	hippuric acid + His-Leu	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.1589	-	IC50: 0.1589 mM	Rattus norvegicus	quercetin-3-O-alpha-(6''-caffeoylglucosyl-beta-1,2-rhamnoside)
0.351	-	IC50: 0.351 mM	Rattus norvegicus	quercetin 3-O-alpha-(6''-p-coumaroylglucosyl-beta -1,2-rhamnoside)
0.3928	-	IC50: 0.3928 mM	Rattus norvegicus	kaempferol-3-alpha-arabinopyranoside
0.4089	-	IC50: 0.4089 mM	Rattus norvegicus	isorhamnetin-3-beta-glucopyranoside
0.7088	-	IC50: 0.7088 mM	Rattus norvegicus	quercetin-3-beta-glucopyranoside

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Release 2023.1 (January 2023)